The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets.

Autor: Alexander SPH; School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK., Kelly E; School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, BS8 1TD, UK., Mathie AA; School of Allied Health Sciences, University of Suffolk, Ipswich, IP4 1QJ, UK., Peters JA; Neuroscience Division, Medical Education Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee, DD1 9SY, UK., Veale EL; Medway School of Pharmacy, The Universities of Greenwich and Kent at Medway, Anson Building, Central Avenue, Chatham Maritime, Chatham, Kent, ME4 4TB, UK., Armstrong JF; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, EH8 9XD, UK., Buneman OP; Laboratory for Foundations of Computer Science, School of Informatics, University of Edinburgh, Edinburgh, EH8 9LE, UK., Faccenda E; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, EH8 9XD, UK., Harding SD; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, EH8 9XD, UK., Spedding M; Spedding Research Solutions SARL, Le Vésinet, 78110, France., Cidlowski JA; National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, 27709, USA., Fabbro D; PIQUR Therapeutics, Basel, 4057, Switzerland., Davenport AP; Clinical Pharmacology Unit, University of Cambridge, Cambridge, CB2 0QQ, UK., Striessnig J; Pharmacology and Toxicology, Institute of Pharmacy, University of Innsbruck, A-6020, Innsbruck, Austria., Davies JA; Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, EH8 9XD, UK., Ahlers-Dannen KE; University of Iowa, Iowa City, USA., Alqinyah M; University of Georgia, Athens, USA., Arumugam TV; National University of Singapore, Singapore, Singapore., Bodle C; University of Pittsburgh, Iowa City, USA., Dagner JB; University of Georgia, Athens, USA., Chakravarti B; University of Iowa, Iowa City, USA., Choudhuri SP; University of Texas Southwestern Medical Center, Dallas, USA., Druey KM; National Institute of Health, Bethesda, USA., Fisher RA; University of Iowa, Iowa City, USA., Gerber KJ; Tetracore Inc., Athens, USA., Hepler JR; Emory University, Athens, USA., Hooks SB; University of Georgia, Athens, USA., Kantheti HS; University of Texas Southwestern Medical Center, Dallas, USA., Karaj B; University of Michigan, East Lansing, USA., Layeghi-Ghalehsoukhteh S; Cobel Darou, Shiraz, Iran., Lee JK; University of Georgia, Athens, USA., Luo Z; University of Iowa, Iowa City, USA., Martemyanov K; Scripps Research Institute, Jupiter, USA., Mascarenhas LD; University of Texas Southwestern Medical Center, Dallas, USA., McNabb H; Purdue University, West Lafayette, USA., Montañez-Miranda C; Emory University, Athens, USA., Ogujiofor O; University of Texas Southwestern Medical Center, Dallas, USA., Phan H; University of Michigan, East Lansing, USA., Roman DL; University of Iowa, Iowa City, USA., Shaw V; Michigan State University, East Lansing, USA., Sjogren B; Purdue University, West Lafayette, USA., Sobey C; La Trobe University, Clayton, Australia., Spicer MM; University of Iowa, Iowa City, USA., Squires KE; Emory University, Athens, USA., Sutton L; University of Maryland, Jupiter, USA., Wendimu M; University of Georgia, Athens, USA., Wilkie T; University of Texas Southwestern Medical Center, Dallas, USA., Xie K; Scripps Research Institute, Jupiter, USA., Zhang Q; Purdue University, West Lafayette, USA., Zolghadri Y; University of Texas Southwestern Medical Center, Dallas, USA.
Jazyk: angličtina
Zdroj: British journal of pharmacology [Br J Pharmacol] 2023 Oct; Vol. 180 Suppl 2, pp. S1-S22.
DOI: 10.1111/bph.16176
Abstrakt: The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.16176. In addition to this overview, in which are identified 'Other protein targets' which fall outside of the subsequent categorisation, there are six areas of focus: G protein-coupled receptors, ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
(© 2023 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of The British Pharmacological Society.)
Databáze: MEDLINE
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