Fractionation, identification of chemical constituents, and biological properties of cashew ( Anacardium occidentale L.) leaf extracts.

Autor: Pham DC; Faculty of Applied Sciences Ton Duc Thang University Ho Chi Minh City Vietnam., Truong DH; Faculty of Applied Sciences Ton Duc Thang University Ho Chi Minh City Vietnam., Tran QH; Faculty of Applied Sciences Ton Duc Thang University Ho Chi Minh City Vietnam., Ho QT; Faculty of Applied Sciences Ton Duc Thang University Ho Chi Minh City Vietnam., Nguyen TAD; Faculty of Applied Sciences Ton Duc Thang University Ho Chi Minh City Vietnam., Nguyen TNH; Faculty of Applied Sciences Ton Duc Thang University Ho Chi Minh City Vietnam., Nguyen TV; Faculty of Applied Sciences Ton Duc Thang University Ho Chi Minh City Vietnam., Nguyen TTV; Faculty of Applied Sciences Ton Duc Thang University Ho Chi Minh City Vietnam., Cao TS; Faculty of Applied Sciences Ton Duc Thang University Ho Chi Minh City Vietnam., Barrow CJ; Centre for Sustainable Bioproducts Deakin University Geelong Victoria Australia., Nguyen HC; Centre for Sustainable Bioproducts Deakin University Geelong Victoria Australia.
Jazyk: angličtina
Zdroj: Food science & nutrition [Food Sci Nutr] 2023 Sep 23; Vol. 11 (12), pp. 7996-8008. Date of Electronic Publication: 2023 Sep 23 (Print Publication: 2023).
DOI: 10.1002/fsn3.3718
Abstrakt: The current study aimed to identify the chemical constituents and bioactivities of the crude ethanolic extract (CEE) and its fractions (ethyl acetate (EAF), hexane (HEF), and aqueous (AEF)) from leaves of cashew ( Anacardium occidentale L.) grown in Vietnam. A total of 31 compounds which belong to alkanes, hydrocarbons, iodine, terpenoids, phenolics, and flavonoids were determined by a gas chromatography-mass spectrometry (GC-MS) analysis, with bis(2-ethylhexyl) phthalate being the most prevailing compound. The highest total phenolic and flavonoid contents were obtained in the EAF, followed by HEF, CEE, and AQF. All samples showed promising in vitro antibacterial activity, enzyme inhibition, and anticancer activity. Among the samples tested, the EAF exhibited the highest enzyme inhibition activity against α-amylase and α-glucosidase (IC 50 values of 51.24 μg/mL and 99.29 μg/mL, respectively), cytotoxicity activity against HeLa cells (IC 50 value of 79.49 μg/mL), and antibacterial activity against Bacillus subtilis and Escherichia coli with MIC values of 5 mg/mL and 2.5 mg/mL, respectively. These findings suggest that the leaves of A. occidentale cultivated in Vietnam are a promising source of bioactive components and that EAF is a promising bioactive material warranting further pharmaceutical investigation.
Competing Interests: The authors have declared no conflicts of interest for this article.
(© 2023 The Authors. Food Science & Nutrition published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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