Serological evidence of virus infection in Eidolon helvum fruit bats: implications for bushmeat consumption in Nigeria.
| Autor: | Cantoni D; Viral Pseudotype Unit, Medway School of Pharmacy, Universities of Kent and Greenwich, Chatham, United Kingdom., Mayora-Neto M; Viral Pseudotype Unit, Medway School of Pharmacy, Universities of Kent and Greenwich, Chatham, United Kingdom., Derveni M; Viral Pseudotype Unit, School of Life Sciences, University of Sussex, Brighton, United Kingdom., da Costa K; Viral Pseudotype Unit, Medway School of Pharmacy, Universities of Kent and Greenwich, Chatham, United Kingdom., Del Rosario J; Viral Pseudotype Unit, Medway School of Pharmacy, Universities of Kent and Greenwich, Chatham, United Kingdom., Ameh VO; Department of Veterinary Public Health and Preventive Medicine, College of Veterinary Medicine, Federal University of Agriculture Makurdi, Makurdi, Nigeria.; Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa., Sabeta CT; Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.; World Organisation for Animal Health Rabies Reference Laboratory, Agricultural Research Council-Onderstepoort Veterinary Research, Onderstepoort, South Africa., Auld B; Viral Pseudotype Unit, School of Life Sciences, University of Sussex, Brighton, United Kingdom., Hamlet A; Department of Infectious Disease Epidemiology, MRC Centre for Global Infectious Disease Analysis, Imperial College London, London, United Kingdom., Jones IM; School of Biological Sciences, University of Reading, Reading, United Kingdom., Wright E; Viral Pseudotype Unit, School of Life Sciences, University of Sussex, Brighton, United Kingdom., Scott SD; Viral Pseudotype Unit, Medway School of Pharmacy, Universities of Kent and Greenwich, Chatham, United Kingdom., Giotis ES; Department of Infectious Diseases, Imperial College London, London, United Kingdom.; School of Life Sciences, University of Essex, Colchester, United Kingdom., Banyard AC; Animal and Plant Health Agency, Weybridge, United Kingdom., Temperton N; Viral Pseudotype Unit, Medway School of Pharmacy, Universities of Kent and Greenwich, Chatham, United Kingdom. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in public health [Front Public Health] 2023 Nov 27; Vol. 11, pp. 1283113. Date of Electronic Publication: 2023 Nov 27 (Print Publication: 2023). |
| DOI: | 10.3389/fpubh.2023.1283113 |
| Abstrakt: | Introduction: The Eidolon helvum fruit bat is one of the most widely distributed fruit bats in Africa and known to be a reservoir for several pathogenic viruses that can cause disease in animals and humans. To assess the risk of zoonotic spillover, we conducted a serological survey of 304 serum samples from E. helvum bats that were captured for human consumption in Makurdi, Nigeria. Methods: Using pseudotyped viruses, we screened 304 serum samples for neutralizing antibodies against viruses from the Coronaviridae, Filoviridae, Orthomyxoviridae and Paramyxoviridae families. Results: We report the presence of neutralizing antibodies against henipavirus lineage GH-M74a virus (odds ratio 6.23; p < 0.001), Nipah virus (odds ratio 4.04; p = 0.00031), bat influenza H17N10 virus (odds ratio 7.25; p < 0.001) and no significant association with Ebola virus (odds ratio 0.56; p = 0.375) in this bat cohort. Conclusion: The data suggest a potential risk of zoonotic spillover including the possible circulation of highly pathogenic viruses in E. helvum populations. These findings highlight the importance of maintaining sero-surveillance of E. helvum, and the necessity for further, more comprehensive investigations to monitor changes in virus prevalence, distribution over time, and across different geographic locations. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer WM declared a shared affiliation with the authors VA and CS to the handling editor at the time of review. (Copyright © 2023 Cantoni, Mayora-Neto, Derveni, da Costa, Del Rosario, Ameh, Sabeta, Auld, Hamlet, Jones, Wright, Scott, Giotis, Banyard and Temperton.) |
| Databáze: | MEDLINE |
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