| Autor: |
Baleva MV; Faculty of Biology, Lomonosov Moscow State University, Moscow, 119234, Russia., Piunova UE; Faculty of Biology, Lomonosov Moscow State University, Moscow, 119234, Russia., Chicherin IV; Faculty of Biology, Lomonosov Moscow State University, Moscow, 119234, Russia., Levitskii SA; Faculty of Biology, Lomonosov Moscow State University, Moscow, 119234, Russia., Kamenski PA; Faculty of Biology, Lomonosov Moscow State University, Moscow, 119234, Russia. piotr.kamenski@gmail.com. |
| Jazyk: |
angličtina |
| Zdroj: |
Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2023 Nov; Vol. 88 (11), pp. 1832-1843. |
| DOI: |
10.1134/S0006297923110135 |
| Abstrakt: |
The evolution of mitochondria has proceeded independently in different eukaryotic lines, which is reflected in the diversity of mitochondrial genomes and mechanisms of their expression in eukaryotic species. Mitochondria have lost most of bacterial ancestor genes by transferring them to the nucleus or eliminating them. However, mitochondria of almost all eukaryotic cells still retain relatively small genomes, as well as their replication, transcription, and translation apparatuses. The dependence on the nuclear genome, specific features of mitochondrial transcripts, and synthesis of highly hydrophobic membrane proteins in the mitochondria have led to significant changes in the translation apparatus inherited from the bacterial ancestor, which retained the basic structure necessary for protein synthesis but became more specialized and labile. In this review, we discuss specific properties of translation initiation in the mitochondria and how the evolution of mitochondria affected the functions of main factors initiating protein biosynthesis in these organelles. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
|
Nepřihlášeným uživatelům se plný text nezobrazuje |
K zobrazení výsledku je třeba se přihlásit.
|
