PlAtg8-mediated autophagy regulates vegetative growth, sporangial cleavage, and pathogenesis in Peronophythora litchii .

Autor:	Yu G; School of Tropical Agriculture and Forestry, School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication), Hainan University , Sanya, China.; Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests, Ministry of Education, Hainan University , Haikou, China., Li W; Fujian Key Laboratory for Monitoring and Integrated Management of Crop Pests, Institute of Plant Protection, Fujian Academy of Agricultural Sciences , Fuzhou, China., Yang C; School of Tropical Agriculture and Forestry, School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication), Hainan University , Sanya, China.; Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests, Ministry of Education, Hainan University , Haikou, China., Zhang X; School of Tropical Agriculture and Forestry, School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication), Hainan University , Sanya, China.; Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests, Ministry of Education, Hainan University , Haikou, China., Luo M; School of Tropical Agriculture and Forestry, School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication), Hainan University , Sanya, China.; Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests, Ministry of Education, Hainan University , Haikou, China., Chen T; School of Tropical Agriculture and Forestry, School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication), Hainan University , Sanya, China.; Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests, Ministry of Education, Hainan University , Haikou, China., Wang X; School of Tropical Agriculture and Forestry, School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication), Hainan University , Sanya, China.; Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests, Ministry of Education, Hainan University , Haikou, China., Wang R; Fujian Key Laboratory for Monitoring and Integrated Management of Crop Pests, Institute of Plant Protection, Fujian Academy of Agricultural Sciences , Fuzhou, China., Chen Q; School of Tropical Agriculture and Forestry, School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication), Hainan University , Sanya, China.; Key Laboratory of Green Prevention and Control of Tropical Plant Diseases and Pests, Ministry of Education, Hainan University , Haikou, China.
Jazyk:	angličtina
Zdroj:	Microbiology spectrum [Microbiol Spectr] 2024 Jan 11; Vol. 12 (1), pp. e0353123. Date of Electronic Publication: 2023 Dec 12.
DOI:	10.1128/spectrum.03531-23
Abstrakt:	Importance: Peronophythora litchii is the pathogen of litchi downy blight, which is the most serious disease in litchi. Autophagy is an evolutionarily conserved catabolic process in eukaryotes. Atg8 is a core protein of the autophagic pathway, which modulates growth and pathogenicity in the oomycete P. litchii . In P. litchii , CRISPR/Cas9-mediated knockout of the PlATG8 impaired autophagosome formation. PlATG8 knockout mutants exhibited attenuated colony expansion, sporangia production, zoospore discharge, and virulence on litchi leaves and fruits. The reduction in zoospore release was likely underpinned by impaired sporangial cleavage. Thus, in addition to governing autophagic flux, PlAtg8 is indispensable for vegetative growth and infection of P. litchii . Competing Interests: The authors declare no conflict of interest.
Databáze:	MEDLINE
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