Durable nonenzymatic electrochemical sensing using silver decorated multi-walled carbon nanotubes for uric acid detection.

Autor:	Anshori I; Bandung Institute of Technology, Jl. Ganesha, Bandung, Bandung, 40132, INDONESIA., Ula LR; Bandung Institute of Technology, Jl Ganesha, Bandung, Bandung, Jawa Barat, 40132, INDONESIA., Asih GIN; Bandung Institute of Technology, Jl Ganesha, Bandung, Jawa Barat, 40132, INDONESIA., Ariasena E; Bandung Institute of Technology, Jl. Ganesha, Bandung, Jawa Barat, 40132, INDONESIA., Uperianti U; Bandung Institute of Technology, Jl. Ganesha, Bandung, Jawa Barat, 40132, INDONESIA., Raditya AN; Bandung Institute of Technology, Jl. Ganesha, Bandung, Jawa Barat, 40132, INDONESIA., Mulyaningsih Y; Sampoerna University, Jakarta, South Jakarta, DKI Jakarta, 12780, INDONESIA., Handayani M; National Research and Innovation Agency Republic of Indonesia, Puspitek, Serpong, Jakarta Pusat, DKI Jakarta, 10340, INDONESIA., Purwidyantri A; School of Chemistry and Chemical Engineering, Queen's University Belfast, David Keir Building, Stranmillis Road, Belfast, BT9 5AG, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND., Prabowo BA; Mathematics and Physics, Queen's University Belfast, University Road, Belfast, BT7 1NN, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
Jazyk:	angličtina
Zdroj:	Nanotechnology [Nanotechnology] 2023 Dec 11. Date of Electronic Publication: 2023 Dec 11.
DOI:	10.1088/1361-6528/ad143f
Abstrakt:	In this study, we demonstrate a facile, durable, and inexpensive technique of producing silver nanoparticles-decorated multi-walled carbon nanotubes (MWCNT/AgNP) on the easy-to-use screen-printed carbon electrodes (SPCE) for non-enzymatic detection of uric acid (UA) in an electrochemical sensor. The developed sensors show great durability for three months in storage, and high specificity performance for preclinical study using spiked UA in a synthetic urine sample. A simple route for this hybrid nanocomposite was proposed through an oxidation-reduction with reflux (ORR) process. A significant increase in the electroactive surface area of SPCE was achieved by modifying it with MWCNT/AgNP. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), Fourier-transform infrared (FT-IR) spectroscopy, Raman spectroscopy, and X-ray diffraction (XRD) analysis confirmed this synthesis. The nanocomposite nanostructure electrodes achieved an outstanding UA detection with a sensitivity of 0.1021 µA/µM and a wide dynamic range of 10-1000 µM. In PBS, the measurements achieved a detection limit of 84.04 nM while in pure synthetic urine; it was 6.074 µM. The constructed sensor exhibits excellent stability and durability for several months, and great specificity against interfering compounds, including dopamine (DA), urea, and glucose. Overall, the present outcomes denote the potential of MWCNT/AgNP-decorated SPCE for early uric acid diagnostics tools in health monitoring. (Creative Commons Attribution license.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu