| Autor: |
Gao Y; Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. |
| Jazyk: |
angličtina |
| Zdroj: |
DNA and cell biology [DNA Cell Biol] 2024 Feb; Vol. 43 (2), pp. 57-60. Date of Electronic Publication: 2023 Dec 11. |
| DOI: |
10.1089/dna.2023.0368 |
| Abstrakt: |
Vesicular stomatitis virus (VSV) is a promising oncolytic virus for treating solid tumors. We recently engineered a replicating VSV that specifically targets and destroys Her2/neu -expressing cancer cells. This virus was created by eliminating its natural binding site and adding a coding sequence for a single chain antibody to the Her2/neu receptor into its genome. Such an approach can be tailored to target various cellular surface molecules. This mini review will discuss genomic modifications of VSVs and their role in oncolytic therapy and discuss some challenges for moving VSVs to clinical applications. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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