The state-of-the-art technic of stereotactic radioablation for the treatment of cardiac arrhythmias: An overview.

Autor: MasoudKabir F; Cardiac Primary Prevention Research Center Tehran University of Medical Sciences Tehran Iran.; Department of Cardiac Electrophysiology, Tehran Heart Center Tehran University of Medical Sciences Tehran Iran., Bayani R; Department of Radiation Oncology Hamadan University of Medical Sciences Hamadan Iran., Mousavi Darzikolaee N; Radiation Oncology Research Center (RORC) Tehran University of Medical Sciences Tehran Iran.; Department of Radiation Oncology, Imam Khomeini Hospital Complex Tehran University of Medical Sciences Tehran Iran., Abdshah A; School of Medicine Tehran University of Medical Sciences Tehran Iran.; Division of Biostatistics University of Miami Miller School of Medicine Miami Florida USA., Moshtaghian M; Cancer Research Center, Cancer institute of Iran, Imam Khomeini Hospital Complex Tehran University of Medical Sciences Tehran Iran., Farhan F; Cancer Research Center, Cancer institute of Iran, Imam Khomeini Hospital Complex Tehran University of Medical Sciences Tehran Iran., Aghili M; Cancer Research Center, Cancer institute of Iran, Imam Khomeini Hospital Complex Tehran University of Medical Sciences Tehran Iran., Kazemian A; Department of Radiation Oncology, Imam Khomeini Hospital Complex Tehran University of Medical Sciences Tehran Iran.; Cancer Research Center, Cancer institute of Iran, Imam Khomeini Hospital Complex Tehran University of Medical Sciences Tehran Iran., Nicosia L; Advanced Radiation Oncology Department IRCCS Ospedale Sacro Cuore Don Calabria Negrar-Verona Italy., Cuccia F; Advanced Radiation Oncology Department IRCCS Ospedale Sacro Cuore Don Calabria Negrar-Verona Italy., Rocha AV; Division of Medicine Federal University of Goias Goiânia Brazil., Jafari F; Cancer Research Center, Cancer institute of Iran, Imam Khomeini Hospital Complex Tehran University of Medical Sciences Tehran Iran., Alongi F; Advanced Radiation Oncology Department IRCCS Ospedale Sacro Cuore Don Calabria Negrar-Verona Italy.; University of Brescia Brescia Italy.
Jazyk: angličtina
Zdroj: Health science reports [Health Sci Rep] 2023 Dec 08; Vol. 6 (12), pp. e1741. Date of Electronic Publication: 2023 Dec 08 (Print Publication: 2023).
DOI: 10.1002/hsr2.1741
Abstrakt: Introduction: Cardiac arrhythmias, including ventricular tachycardia (VT), stand as a significant threat to health, often leading to mortality and sudden cardiac death. While conventional treatments for VT exhibit efficacy, cases of refractory VT pose challenges. Stereotactic Arrhythmia Radioablation (STAR) offers a novel approach, delivering precise high-dose radiation to well-defined targets with minimal collateral damage. This study explores the potential of STAR as an alternative therapy, especially for high-risk patients or those with refractory VT.
Methods: This research reviews ongoing studies and preliminary investigations into the evaluation of the efficacy and safety of STAR. The method involves targeted radiation delivery, assessing reductions in VT recurrence and the early safety profile in refractory VT patients. However, given STAR's early stage and limited clinical evidence, cautious interpretation is advised.
Results: Preliminary findings indicate a reduction in VT recurrence with STAR, suggesting promise as a therapeutic option. Early safety profiles are encouraging, but definitive statements on efficacy and safety require further investigation. Positive initial outcomes underscore the need for additional data and long-term studies.
Conclusion: Stereotactic Arrhythmia Radioablation is recently emerging as a promising treatment for refractory VT. While early results are encouraging, careful interpretation is needed, due to STAR's early stages. Ongoing investigations are critical for a comprehensive understanding of its long-term efficacy and tolerability. This review provides fundamental insights into STAR's background, principles, pre-treatment procedures, clinical implications, and toxicity, setting the stage for future research in this evolving therapeutic field.
Competing Interests: There are no conflicts of interest to report. This is a review article. No human subjects were involved, and no consent was needed.
(© 2023 The Authors. Health Science Reports published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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