The importance of REM sleep fragmentation in the effects of stress on sleep: Perspectives from preclinical studies.
| Autor: | Grafe L; Department of Psychology, Bryn Mawr College, Bryn Mawr, PA, USA., Miller KE; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA., Ross RJ; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Psychiatry, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Bhatnagar S; Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, Philadelphia, PA, USA.; Department of Anesthesiology and Critical Care, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. |
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| Jazyk: | angličtina |
| Zdroj: | Neurobiology of stress [Neurobiol Stress] 2023 Nov 14; Vol. 28, pp. 100588. Date of Electronic Publication: 2023 Nov 14 (Print Publication: 2024). |
| DOI: | 10.1016/j.ynstr.2023.100588 |
| Abstrakt: | Psychological stress poses a risk for sleep disturbances. Importantly, trauma-exposed individuals who develop posttraumatic stress disorder (PTSD) frequently report insomnia and recurrent nightmares. Clinical studies have provided insight into the mechanisms of these sleep disturbances. We review polysomnographic findings in PTSD and identify analogous measures that have been made in animal models of PTSD. There is a rich empirical and theoretical literature on rapid eye movement sleep (REMS) substrates of insomnia and nightmares, with an emphasis on REMS fragmentation. For future investigations of stress-induced sleep changes, we recommend a focus on tonic, phasic and other microarchitectural REMS measures. Power spectral density analysis of the sleep EEG should also be utilized. Animal models with high construct validity can provide insight into gender and time following stressor exposure as moderating variables. Ultimately, preclinical studies with translational potential will lead to improved treatment for stress-related sleep disturbances. Competing Interests: The authors have no conflicts of interest to declare. (© 2023 The Authors.) |
| Databáze: | MEDLINE |
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