| Autor: |
Tapia-González A; Laboratorio de Proteómica e Inmunometabolismo, Hospital General de México 'Dr. Eduardo Liceaga', Mexico City 06720, Mexico., Vélez-Ixta JM; Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City 07360, Mexico., Bueno-Hernández N; Laboratorio de Proteómica e Inmunometabolismo, Hospital General de México 'Dr. Eduardo Liceaga', Mexico City 06720, Mexico., Piña-Escobedo A; Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City 07360, Mexico., Briones-Garduño JC; Servicio de Ginecología, Hospital General de México 'Dr. Eduardo Liceaga', Mexico City 06720, Mexico., de la Rosa-Ruiz L; Banco de Leche Humana y Lactancia, Hospital General de México 'Dr. Eduardo Liceaga', Mexico City 06720, Mexico., Aguayo-Guerrero J; Laboratorio de Proteómica e Inmunometabolismo, Hospital General de México 'Dr. Eduardo Liceaga', Mexico City 06720, Mexico., Mendoza-Martínez VM; Laboratorio de Proteómica e Inmunometabolismo, Hospital General de México 'Dr. Eduardo Liceaga', Mexico City 06720, Mexico., Snowball-Del-Pilar L; Laboratorio de Proteómica e Inmunometabolismo, Hospital General de México 'Dr. Eduardo Liceaga', Mexico City 06720, Mexico., Escobedo G; Laboratorio de Proteómica e Inmunometabolismo, Hospital General de México 'Dr. Eduardo Liceaga', Mexico City 06720, Mexico., Meléndez-Mier G; Facultad de Salud Pública y Nutrición, Universidad Autónoma de Monterrey, Monterrey 64460, Mexico., Méndez-García LA; Laboratorio de Proteómica e Inmunometabolismo, Hospital General de México 'Dr. Eduardo Liceaga', Mexico City 06720, Mexico., García-Mena J; Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City 07360, Mexico., Esquivel-Velázquez M; Laboratorio de Proteómica e Inmunometabolismo, Hospital General de México 'Dr. Eduardo Liceaga', Mexico City 06720, Mexico. |
| Abstrakt: |
Non-nutritive sweeteners (NNSs) provide a sweet taste to foods and beverages without significantly adding calories. Still, their consumption has been linked to modifications in adult's and children's gut microbiota and the disruption of blood glucose control. Human milk microbiota are paramount in establishing infants' gut microbiota, but very little is known about whether the consumption of sweeteners can alter it. To address this question, we sequenced DNA extracted colostrum samples from a group of mothers, who had different levels of NNS consumption, using the Ion Torrent Platform. Our results show that the "core" of colostrum microbiota, composed of the genera Bifidobacterium , Blautia , Cutibacteium , Staphylococcus , and Streptococcus , remains practically unchanged with the consumption of NNS during pregnancy, but specific genera display significant alterations, such as Staphylococcus and Streptococcus . A significant increase in the unclassified archaea Methanobrevibacter spp. was observed as the consumption frequency of NNS increased. The increase in the abundance of this archaea has been previously linked to obesity in Mexican children. NNS consumption during pregnancy could be related to changes in colostrum microbiota and may affect infants' gut microbiota seeding and their future health. |
