Usefulness of Peripheral Blood Cultures in Children With Cancer and Episodes of Fever and Neutropenia.

Autor:	Sarquis T; Department of Pediatrics and Pediatric Surgery, Hospital Roberto del Rio, Facultad de Medicina, Universidad de Chile, Santiago, Chile., Ibáñez C; Department of Pediatrics and Pediatric Surgery, Hospital Luis Calvo Mackenna, Facultad de Medicina, Universidad de Chile, Santiago, Chile., De La Maza V; Department of Pediatrics and Pediatric Surgery, Hospital Luis Calvo Mackenna, Facultad de Medicina, Universidad de Chile, Santiago, Chile., Valenzuela R; Department of Pediatrics and Pediatric Surgery, Hospital Luis Calvo Mackenna, Facultad de Medicina, Universidad de Chile, Santiago, Chile., Zubieta M; Departamento de Pediatría y Cirugía Infantil Sur, Hospital Dr. Exequiel González Cortés, Pediatría Sur, Santiago, Chile.; Committee of Infectious Diseases, National Child Program of Antineoplastic Drugs (PINDA), Santiago, Chile., Labraña Y; Committee of Infectious Diseases, National Child Program of Antineoplastic Drugs (PINDA), Santiago, Chile.; Hospital San Juan De Dios, Pediatrics, Santiago, Chile., Gutiérrez V; Committee of Infectious Diseases, National Child Program of Antineoplastic Drugs (PINDA), Santiago, Chile.; Department of Pediatrics, Complejo Asistencial Doctor Sotero del Rio, Santiago, Chile., Greppi C; Committee of Infectious Diseases, National Child Program of Antineoplastic Drugs (PINDA), Santiago, Chile.; Department of Pediatrics and Pediatric Surgery, Hospital Roberto del Rio, Facultad de Medicina, Universidad de Chile, Santiago, Chile., Martínez D; Committee of Infectious Diseases, National Child Program of Antineoplastic Drugs (PINDA), Santiago, Chile.; Hospital San Borja Arriaran, Facultad de Medicina, Universidad de Chile., Díaz P; Committee of Infectious Diseases, National Child Program of Antineoplastic Drugs (PINDA), Santiago, Chile.; Hospital Gustavo Fricke, Pediatrics, Viña del Mar, Chile., Santolaya ME; Department of Infectious Diseases, Hospital Dr. Luis Calvo Mackenna, Faculty of Medicine, Universidad de Chile, Santiago, Chile.
Jazyk:	angličtina
Zdroj:	The Pediatric infectious disease journal [Pediatr Infect Dis J] 2024 Feb 01; Vol. 43 (2), pp. 160-164. Date of Electronic Publication: 2023 Dec 06.
DOI:	10.1097/INF.0000000000004168
Abstrakt:	Background: The collection of blood cultures (BC) is key for guiding antimicrobial therapy in children with febrile neutropenia (FN), more than 90% have central venous catheters (CVC). There is no consensus on the need for peripheral BC over central BC in this population. The aim of this study was to determine the contribution of peripheral BC over central BC in the diagnosis of bloodstream infections in children with FN. Methods: Descriptive, retrospective study, episodes of FN recorded prospectively in 6 hospitals in Santiago, Chile, from 2016 to 2021. Central and peripheral BC were drawn upon admission. All episodes with at least one (+) BC were allocated to one of these groups: consistent (+) BC, inconsistent (+) BC, only CVC (+) BC and only peripheral (+) BC. The volume of the samples was recorded. Results: The analysis included 241 episodes of FN with at least one (+) BC. The median age was 7.2 years, 51% were female, 84% had hematological cancer and 98% had episodes of high-risk FN. Of a total of 241 episodes, 135 (56%) had consistent (+) BC, 13 (5%) had inconsistent (+) BC, 35 (15%) had only CVC (+) BC and 58 (24%) had only peripheral (+) BC. There were no significant differences in the volume of the samples between central and peripheral BC. Conclusions: The proportion of bloodstream infections detected only through peripheral BC was 24%, higher than previously reported, not due to sample volume. We recommend obtaining peripheral as well CVC BC in children with FN. Competing Interests: The authors have no conflicts of interest to disclose. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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