Long-term influence of sleep/wake history on the dynamic neurobehavioural response to sustained sleep restriction.

Autor: Banks S; Behaviour-Brain-Body Research Centre, University of South Australia, Adelaide, South Australia, Australia., Jones CW; Unit for Experimental Psychiatry, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., McCauley ME; Sleep and Performance Research Center and Department of Translational Medicine and Physiology, Washington State University, Spokane, Washington, USA., Dorrian J; Behaviour-Brain-Body Research Centre, University of South Australia, Adelaide, South Australia, Australia., Basner M; Unit for Experimental Psychiatry, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Maislin G; Biomedical Statistical Consulting, Wynnewood, Pennsylvania, USA., Van Dongen HPA; Sleep and Performance Research Center and Department of Translational Medicine and Physiology, Washington State University, Spokane, Washington, USA., Dinges DF; Unit for Experimental Psychiatry, Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jazyk: angličtina
Zdroj: Journal of sleep research [J Sleep Res] 2024 Aug; Vol. 33 (4), pp. e14117. Date of Electronic Publication: 2023 Dec 07.
DOI: 10.1111/jsr.14117
Abstrakt: Chronic sleep restriction, common in today's 24/7 society, causes cumulative neurobehavioural impairment, but the dynamics of the build-up and dissipation of this impairment have not been fully elucidated. We addressed this knowledge gap in a laboratory study involving two, 5-day periods of sleep restriction to 4 hr per day, separated by a 1-day dose-response intervention sleep opportunity. We measured sleep physiological and waking neurobehavioural responses in 70 healthy adults, each randomized to one of seven dose-response intervention sleep doses ranging from 0 to 12 hr, or a non-sleep-restricted control group. As anticipated, sleep physiological markers showed homeostatic dynamics throughout the study, and waking neurobehavioural impairment accumulated across the two sleep restriction periods. Unexpectedly, there was only a slight and short-lived effect of the 1-day dose-response intervention sleep opportunity. Whether the dose-response intervention sleep opportunity involved extension, further restriction or total deprivation of sleep, neurobehavioural functioning during the subsequent second sleep restriction period was dominated by prior sleep-wake history. Our findings revealed a profound and enduring influence of long-term sleep-wake history as a fundamental aspect of the dynamic regulation of the neurobehavioural response to sleep loss.
(© 2023 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society.)
Databáze: MEDLINE
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