Protocol for the development of a core outcome set for neonatal sepsis (NESCOS).

Autor: Taneri PE; HRB-Trials Methodology Research Network, University of Galway, Galway, Ireland.; School of Nursing and Midwifery, University of Galway, Galway, Ireland., Kirkham JJ; Centre for Biostatistics, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom., Molloy EJ; Department of Neonatology, The Coombe Hospital, Dublin, Ireland.; Department of Paediatrics and Child Health, Trinity College Dublin, Trinity Research in Childhood Centre (TRiCC), Neonatology, Children's Health Ireland, Dublin, Ireland., Biesty L; School of Nursing and Midwifery, University of Galway, Galway, Ireland.; Evidence Synthesis Ireland & Cochrane Ireland, University of Galway, Galway, Ireland., Polin RA; Department of Paediatrics, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America., Wynn JL; Department of Paediatrics, College of Medicine, University of Florida, Gainesville, Florida, United States of America., Stoll BJ; China Medical Board, China.; Emory University School of Medicine, Atlanta, GA, United States of America.; McGovern Medical School of the University of Texas Health Science Center at Houston, Houston, Texas, United States of America., Kissoon N; Department of Paediatrics, College of Medicine, University of British Columbia, Vancouver, Canada., Kawaza K; Department of Paediatrics and Child Health, Kamuzu University of Health Sciences, Blantyre, Malawi., Daly M; Education and Research, Irish Neonatal Health Alliance, Bray, Ireland., Branagan A; Department of Neonatology, The Coombe Hospital, Dublin, Ireland.; Department of Paediatrics and Child Health, Trinity College Dublin, Trinity Research in Childhood Centre (TRiCC), Neonatology, Children's Health Ireland, Dublin, Ireland., Bonnard LN; Patient Advocacy, Melletted a helyem Egyesület, Budapest, Hungary., Giannoni E; Clinic of Neonatology, Department Mother-Woman-Child, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Strunk T; Neonatal Directorate, Child and Adolescent Health Service, Wesfarmers' Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, University of Western Australia, Perth, Australia., Ohaja M; School of Nursing and Midwifery, University of Galway, Galway, Ireland., Mugabe K; Mbale Regional Referral Hospital, Busitema University Faculty of Health Sciences, Mbale, Uganda., Suguitani D; Brazilian Parents of Preemies' Association, Brazil., Quirke F; HRB-Trials Methodology Research Network, University of Galway, Galway, Ireland.; School of Medicine, University of Limerick, Limerick, Ireland., Devane D; HRB-Trials Methodology Research Network, University of Galway, Galway, Ireland.; School of Nursing and Midwifery, University of Galway, Galway, Ireland.; Evidence Synthesis Ireland & Cochrane Ireland, University of Galway, Galway, Ireland.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2023 Dec 05; Vol. 18 (12), pp. e0295325. Date of Electronic Publication: 2023 Dec 05 (Print Publication: 2023).
DOI: 10.1371/journal.pone.0295325
Abstrakt: Neonatal sepsis is a serious public health problem; however, there is substantial heterogeneity in the outcomes measured and reported in research evaluating the effectiveness of the treatments. Therefore, we aim to develop a Core Outcome Set (COS) for studies evaluating the effectiveness of treatments for neonatal sepsis. Since a systematic review of key outcomes from randomised trials of therapeutic interventions in neonatal sepsis was published recently, we will complement this with a qualitative systematic review of the key outcomes of neonatal sepsis identified by parents, other family members, parent representatives, healthcare providers, policymakers, and researchers. We will interpret the outcomes of both studies using a previously established framework. Stakeholders across three different groups i.e., (1) researchers, (2) healthcare providers, and (3) patients' parents/family members and parent representatives will rate the importance of the outcomes in an online Real-Time Delphi Survey. Afterwards, consensus meetings will be held to agree on the final COS through online discussions with key stakeholders. This COS is expected to minimize outcome heterogeneity in measurements and publications, improve comparability and synthesis, and decrease research waste.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2023 Taneri et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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