Effects of testosterone enanthate on aggression, risk-taking, competition, mood, and other cognitive domains during 28 days of severe energy deprivation.

Autor:	Lieberman HR; Military Nutrition Division, US Army Research Institute of Environmental Medicine (USARIEM), Natick, MA, 01760-5007, USA. harris.r.lieberman.civ@health.mil.; University of Toronto, Toronto, ON, Canada. harris.r.lieberman.civ@health.mil., Caldwell JA; Military Nutrition Division, US Army Research Institute of Environmental Medicine (USARIEM), Natick, MA, 01760-5007, USA.; University of Toronto, Toronto, ON, Canada.; Laulima Government Solutions, Frederick, MD, USA., Vartanian O; University of Toronto, Toronto, ON, Canada.; Defence Research and Development Canada, Toronto, ON, Canada., Carmichael OT; University of Toronto, Toronto, ON, Canada.; Louisiana State University's Pennington Biomedical Research Center, Baton Rouge, LA, USA., Karl JP; Military Nutrition Division, US Army Research Institute of Environmental Medicine (USARIEM), Natick, MA, 01760-5007, USA.; University of Toronto, Toronto, ON, Canada., Berryman CE; Military Nutrition Division, US Army Research Institute of Environmental Medicine (USARIEM), Natick, MA, 01760-5007, USA.; University of Toronto, Toronto, ON, Canada.; Louisiana State University's Pennington Biomedical Research Center, Baton Rouge, LA, USA., Gadde KM; University of Toronto, Toronto, ON, Canada.; Louisiana State University's Pennington Biomedical Research Center, Baton Rouge, LA, USA.; Department of Surgery, University of California Irvine, Orange, CA, USA., Niro PJ; Military Nutrition Division, US Army Research Institute of Environmental Medicine (USARIEM), Natick, MA, 01760-5007, USA.; University of Toronto, Toronto, ON, Canada., Harris MN; University of Toronto, Toronto, ON, Canada.; Louisiana State University's Pennington Biomedical Research Center, Baton Rouge, LA, USA., Rood JC; University of Toronto, Toronto, ON, Canada.; Louisiana State University's Pennington Biomedical Research Center, Baton Rouge, LA, USA., Pasiakos SM; Military Nutrition Division, US Army Research Institute of Environmental Medicine (USARIEM), Natick, MA, 01760-5007, USA.; University of Toronto, Toronto, ON, Canada.; Office of Dietary Supplements, National Institutes of Health, Bethesda, MD, USA.
Jazyk:	angličtina
Zdroj:	Psychopharmacology [Psychopharmacology (Berl)] 2024 Mar; Vol. 241 (3), pp. 461-478. Date of Electronic Publication: 2023 Dec 01.
DOI:	10.1007/s00213-023-06502-8
Abstrakt:	Rationale: Behavioral effects of testosterone depend on dose, acute versus sustained formulation, duration of administration, personality, genetics, and endogenous levels of testosterone. There are also considerable differences between effects of endogenous and exogenous testosterone. Objectives: This study was the secondary behavioral arm of a registered clinical trial designed to determine if testosterone protects against loss of lean body mass and lower-body muscle function induced by a severe energy deficit typical of sustained military operations. Methods: Behavioral effects of repeated doses of testosterone on healthy young men whose testosterone was reduced by severe energy deficit were examined. This was a double-blind, placebo-controlled, between-group study. Effects of four weekly intramuscular injections of testosterone enanthate (200 mg/week, N = 24) or matching placebo (N = 26) were evaluated. Determination of sample size was based on changes in lean body mass. Tasks assessing aggression, risk-taking, competition, social cognition, vigilance, memory, executive function, and mood were repeatedly administered. Results: During a period of artificially induced, low testosterone levels, consistent behavioral effects of administration of exogenous testosterone were not observed. Conclusions: Exogeneous testosterone enanthate (200 mg/week) during severe energy restriction did not reliably alter the measures of cognition. Study limitations include the relatively small sample size compared to many studies of acute testosterone administration. The findings are specific to healthy males experiencing severe energy deficit and should not be generalized to effects of other doses, formulations, or acute administration of endogenous testosterone or studies conducted with larger samples using tests of cognitive function designed to detect specific effects of testosterone. (© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.)
Databáze:	MEDLINE
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