Ten years of injectable platelet-rich fibrin.

Autor: Miron RJ; Department of Periodontology, University of Bern, Bern, Switzerland., Gruber R; Department of Oral Biology, Medical University of Vienna, Vienna, Austria., Farshidfar N; Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran., Sculean A; Department of Periodontology, University of Bern, Bern, Switzerland., Zhang Y; Department of Oral Implantology, University of Wuhan, Wuhan, China.
Jazyk: angličtina
Zdroj: Periodontology 2000 [Periodontol 2000] 2024 Feb; Vol. 94 (1), pp. 92-113. Date of Electronic Publication: 2023 Nov 30.
DOI: 10.1111/prd.12538
Abstrakt: The use of platelet-rich fibrin (PRF) has seen widespread advantages over platelet-rich plasma (PRP) in many fields of medicine. However, until 2014, PRF remained clinically available only in its solid clotted form. Modifications to centrifugation protocols and tube technology have led to the development of a liquid injectable version of PRF (i-PRF). This narrative review takes a look back at the technological developments made throughout the past decade and further elaborates on their future clinical applications. Topics covered include improvements in isolation techniques and protocols, ways to further concentrate i-PRF, and the clinical impact and relevance of cooling i-PRF. Next, various uses of i-PRF are discussed, including its use in regenerative periodontology, implantology, endodontics, temporomandibular joint injections, and orthodontic tooth movement. Furthermore, various indications in medicine are also covered, including its use in sports injuries and osteoarthritis of various joints, treatment of diabetic ulcers/wound care, and facial esthetics and hair regrowth. Finally, future applications are discussed, mainly its use as a drug delivery vehicle for small biomolecules, such as growth factors, antibiotics, exosomes, and other medications that may benefit from the controlled and gradual release of biomolecules over time.
(© 2023 The Authors. Periodontology 2000 published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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