The Cholesterol-5,6-Epoxide Hydrolase: A Metabolic Checkpoint in Several Diseases.

Autor:	de Medina P; Cancer Research Center of Toulouse (CRCT), Inserm, CNRS, University of Toulouse, Team INOV: 'Cholesterol Metabolism and Therapeutic Innovations', Toulouse, France.; Equipe labellisée par la Ligue Nationale contre le Cancer, Toulouse, France.; French Network for Nutrition Physical Activity and Cancer Research (NACRe Network), Jouy-en-Josas, France., Ayadi S; Cancer Research Center of Toulouse (CRCT), Inserm, CNRS, University of Toulouse, Team INOV: 'Cholesterol Metabolism and Therapeutic Innovations', Toulouse, France.; Equipe labellisée par la Ligue Nationale contre le Cancer, Toulouse, France.; French Network for Nutrition Physical Activity and Cancer Research (NACRe Network), Jouy-en-Josas, France., Diallo K; Cancer Research Center of Toulouse (CRCT), Inserm, CNRS, University of Toulouse, Team INOV: 'Cholesterol Metabolism and Therapeutic Innovations', Toulouse, France.; Equipe labellisée par la Ligue Nationale contre le Cancer, Toulouse, France.; French Network for Nutrition Physical Activity and Cancer Research (NACRe Network), Jouy-en-Josas, France., Buñay J; Cancer Research Center of Toulouse (CRCT), Inserm, CNRS, University of Toulouse, Team INOV: 'Cholesterol Metabolism and Therapeutic Innovations', Toulouse, France.; Equipe labellisée par la Ligue Nationale contre le Cancer, Toulouse, France.; French Network for Nutrition Physical Activity and Cancer Research (NACRe Network), Jouy-en-Josas, France., Pucheu L; Cancer Research Center of Toulouse (CRCT), Inserm, CNRS, University of Toulouse, Team INOV: 'Cholesterol Metabolism and Therapeutic Innovations', Toulouse, France.; Equipe labellisée par la Ligue Nationale contre le Cancer, Toulouse, France.; French Network for Nutrition Physical Activity and Cancer Research (NACRe Network), Jouy-en-Josas, France., Soulès R; Cancer Research Center of Toulouse (CRCT), Inserm, CNRS, University of Toulouse, Team INOV: 'Cholesterol Metabolism and Therapeutic Innovations', Toulouse, France.; Equipe labellisée par la Ligue Nationale contre le Cancer, Toulouse, France.; French Network for Nutrition Physical Activity and Cancer Research (NACRe Network), Jouy-en-Josas, France., Record M; Cancer Research Center of Toulouse (CRCT), Inserm, CNRS, University of Toulouse, Team INOV: 'Cholesterol Metabolism and Therapeutic Innovations', Toulouse, France.; Equipe labellisée par la Ligue Nationale contre le Cancer, Toulouse, France.; French Network for Nutrition Physical Activity and Cancer Research (NACRe Network), Jouy-en-Josas, France., Brillouet S; Cancer Research Center of Toulouse (CRCT), Inserm, CNRS, University of Toulouse, Team INOV: 'Cholesterol Metabolism and Therapeutic Innovations', Toulouse, France.; Equipe labellisée par la Ligue Nationale contre le Cancer, Toulouse, France.; French Network for Nutrition Physical Activity and Cancer Research (NACRe Network), Jouy-en-Josas, France.; Department of Radiopharmacy, Institut Universitaire du Cancer Toulouse - Oncopole, Toulouse, France., Vija L; Cancer Research Center of Toulouse (CRCT), Inserm, CNRS, University of Toulouse, Team INOV: 'Cholesterol Metabolism and Therapeutic Innovations', Toulouse, France.; Equipe labellisée par la Ligue Nationale contre le Cancer, Toulouse, France.; French Network for Nutrition Physical Activity and Cancer Research (NACRe Network), Jouy-en-Josas, France.; Department of Medical Imaging, Institut Universitaire du Cancer Toulouse - Oncopole, Toulouse, France., Courbon F; Cancer Research Center of Toulouse (CRCT), Inserm, CNRS, University of Toulouse, Team INOV: 'Cholesterol Metabolism and Therapeutic Innovations', Toulouse, France.; Equipe labellisée par la Ligue Nationale contre le Cancer, Toulouse, France.; French Network for Nutrition Physical Activity and Cancer Research (NACRe Network), Jouy-en-Josas, France.; Department of Medical Imaging, Institut Universitaire du Cancer Toulouse - Oncopole, Toulouse, France., Silvente-Poirot S; Cancer Research Center of Toulouse (CRCT), Inserm, CNRS, University of Toulouse, Team INOV: 'Cholesterol Metabolism and Therapeutic Innovations', Toulouse, France.; Equipe labellisée par la Ligue Nationale contre le Cancer, Toulouse, France.; French Network for Nutrition Physical Activity and Cancer Research (NACRe Network), Jouy-en-Josas, France., Poirot M; Cancer Research Center of Toulouse (CRCT), Inserm, CNRS, University of Toulouse, Team INOV: 'Cholesterol Metabolism and Therapeutic Innovations', Toulouse, France. marc.poirot@inserm.fr.; Equipe labellisée par la Ligue Nationale contre le Cancer, Toulouse, France. marc.poirot@inserm.fr.; French Network for Nutrition Physical Activity and Cancer Research (NACRe Network), Jouy-en-Josas, France. marc.poirot@inserm.fr.
Jazyk:	angličtina
Zdroj:	Advances in experimental medicine and biology [Adv Exp Med Biol] 2024; Vol. 1440, pp. 149-161.
DOI:	10.1007/978-3-031-43883-7_8
Abstrakt:	Cholesterol-5,6-epoxides (5,6-ECs) are oxysterols (OS) that have been linked to several pathologies including cancers and neurodegenerative diseases. 5,6-ECs can be produced from cholesterol by several mechanisms including reactive oxygen species, lipoperoxidation, and cytochrome P450 enzymes. 5,6-ECs exist as two different diastereoisomers: 5,6α-EC and 5,6β-EC with different metabolic fates. They can be produced as a mixture or as single products of epoxidation. The epoxide ring of 5,6α-EC and 5,6β-EC is very stable and 5,6-ECs are prone to hydration by the cholesterol-5,6-epoxide hydrolase (ChEH) to give cholestane-3β,5α,6β-triol, which can be further oxidized into oncosterone. 5,6α-EC is prone to chemical and enzymatic conjugation reactions leading to bioactive compounds such as dendrogenins, highlighting the existence of a new metabolic branch on the cholesterol pathway centered on 5,6α-EC. We will summarize in this chapter current knowledge on this pathway which is controlled by the ChEH. (© 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.)
Databáze:	MEDLINE
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