Mechanisms and functions of multiciliary coordination.

Autor: Wan KY; Living Systems Institute, University of Exeter, Stocker Road, EX4 4QD, UK. Electronic address: k.y.wan2@exeter.ac.uk., Poon RN; Living Systems Institute, University of Exeter, Stocker Road, EX4 4QD, UK.
Jazyk: angličtina
Zdroj: Current opinion in cell biology [Curr Opin Cell Biol] 2024 Feb; Vol. 86, pp. 102286. Date of Electronic Publication: 2023 Nov 30.
DOI: 10.1016/j.ceb.2023.102286
Abstrakt: Ciliated organisms are present in virtually every branch of the eukaryotic tree of life. In diverse systems, cilia operate in a coordinated manner to drive fluid flows, or even propel entire organisms. How do groups of motile cilia coordinate their activity within a cell or across a tissue to fulfil essential functions of life? In this review, we highlight the latest developments in our understanding of the mechanisms and functions of multiciliary coordination in diverse systems. We explore new and emerging trends in bioimaging, analytical, and computational methods, which together with their application in new model systems, have conspired to deliver important insights into one of the most fundamental questions in cellular dynamics.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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