Thiamine and benfotiamine: Focus on their therapeutic potential.
| Autor: | Bozic I; Institute for Biological Research 'Sinisa Stankovic'- National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia., Lavrnja I; Institute for Biological Research 'Sinisa Stankovic'- National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia. |
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| Jazyk: | angličtina |
| Zdroj: | Heliyon [Heliyon] 2023 Nov 07; Vol. 9 (11), pp. e21839. Date of Electronic Publication: 2023 Nov 07 (Print Publication: 2023). |
| DOI: | 10.1016/j.heliyon.2023.e21839 |
| Abstrakt: | Thiamine, also known as vitamin B1, is an essential nutrient that plays a crucial role in energy metabolism and overall health. It is a water-soluble vitamin that plays an important role in the conversion of carbohydrates into energy in the body. Thiamine is essential for the proper functioning of the nervous system, heart and muscles. Thiamine deficiency is a life-threatening disease that leads to various disorders and lesions in the nerves and brain, at least in vertebrates. Several thiamine precursors with higher bioavailability have been developed to compensate for thiamine deficiency, including benfotiamine. Benfotiamine is more bioavailable and has higher tissue penetration than thiamine. Studies have shown its antioxidant and anti-inflammatory potential in activated immune and glial cells. It also improves complications observed in type 2 diabetes and has beneficial effects in mouse models of neurodegenerative disease. Benfotiamine represents an off-the-shelf agent used to support nerve health, promote healthy aging and support glucose metabolism. Accordingly, the present review aimed to provide an overview of the neuroprotective effects of thiamine/benfotiamine in the context of inflammation and oxidative stress. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Authors.) |
| Databáze: | MEDLINE |
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