Metabolic Control of Cardiomyocyte Cell Cycle.
| Autor: | Menendez-Montes I; University of Texas Southwestern Medical Center, Dallas, Texas, US., Garry DJ; University of Minnesota, Minneapolis, Minnesota, US., Zhang JJ; University of Alabama Birmingham, Birmingham, Alabama, US., Sadek HA; University of Texas Southwestern Medical Center, Dallas, Texas, US. |
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| Jazyk: | angličtina |
| Zdroj: | Methodist DeBakey cardiovascular journal [Methodist Debakey Cardiovasc J] 2023 Nov 16; Vol. 19 (5), pp. 26-36. Date of Electronic Publication: 2023 Nov 16 (Print Publication: 2023). |
| DOI: | 10.14797/mdcvj.1309 |
| Abstrakt: | Current therapies for heart failure aim to prevent the deleterious remodeling that occurs after MI injury, but currently no therapies are available to replace lost cardiomyocytes. Several organisms now being studied are capable of regenerating their myocardium by the proliferation of existing cardiomyocytes. In this review, we summarize the main metabolic pathways of the mammalian heart and how modulation of these metabolic pathways through genetic and pharmacological approaches influences cardiomyocyte proliferation and heart regeneration. Competing Interests: HAS is supported by NIH R01 HL149137-01, NIH 1P01HL160476-01A1, NIH R35 HL166563-01, and NIH P01HL160488. IM-M is supported by AHA Postdoctoral Fellowship 903385.The authors have no competing interests to declare. (Copyright: © 2023 The Author(s).) |
| Databáze: | MEDLINE |
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