Antihypertensive potential of the stem bark of Canarium schweinfurthii Engl. (Burseraceae) in wistar rats: UPLC-ESI-QToF-MS/MS-based prediction of antihypertensive phytochemicals.
Autor: | Mbosso Teinkela JE; Department of Biological Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, P.O. Box 2701 Douala, Cameroon., Nguemfo EL; Department of Biological Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, P.O. Box 2701 Douala, Cameroon., Fokou Nzodjou T; Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, P.O. Box 2701 Douala, Cameroon., Bogning Zangueu C; Department of Biology and Physiology of Animal Organisms, Faculty of Sciences, University of Douala, P.O. Box 24157 Douala, Cameroon., Kalinski JC; Department of Biochemistry and Microbiology, Faculty of Science, Rhodes University, Makhanda 6140, South Africa., Tsakem B; Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Assob Nguedia JC; Department of Biological Sciences, Faculty of Medicine and Pharmaceutical Sciences, University of Douala, P.O. Box 2701 Douala, Cameroon., Siwe Noundou X; Department of Pharmaceutical Sciences, School of Pharmacy, Sefako Makgatho Health Sciences University, P.O. Box 60, Pretoria 0204, South Africa. |
---|---|
Jazyk: | angličtina |
Zdroj: | Heliyon [Heliyon] 2023 Nov 04; Vol. 9 (11), pp. e21841. Date of Electronic Publication: 2023 Nov 04 (Print Publication: 2023). |
DOI: | 10.1016/j.heliyon.2023.e21841 |
Abstrakt: | Ethnopharmacological Relevance: Canarium schweinfurthii, also called ''Elemierd'Afrique'', is used in Cameroonian folk medicine (bark decoction) to treat patients suffering from hypertension. Aim of the study : This study aimed at evaluating the antihypertensive activities of the stem bark of Canarium schweinfurthii and identifying potential compounds present in its extract that may support or oppose its ethnomedicinial use. Materials and Methods: Stem bark extract of Canarium schweinfurthii was prepared by maceration using 70 % ethanol followed by redissolution in methanol and hyphenated. Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry (UPLC-MS/MS) analysis for the detection and characterisation of secondary metabolites. Antihypertensive effects were assessed in Wistar rats after induction of hypertension with sodium chloride (NaCl) 18 % at a dose of 0.01mL/g Results: The ethanolic bark extract of C. schweinfurthii significantly inhibited the increase of blood pressure with a maximum of 23.18 % (systolic pressure, p < 0.0001), 24.77 % (diastolic pressure, p < 0.001) and 22.95 % (mean pressure, p < 0.0001) at a dose of 200 mg/kg Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2023 The Authors.) |
Databáze: | MEDLINE |
Externí odkaz: |