Multiphasic exercise prehabilitation for patients undergoing surgery for head and neck cancer: a hybrid effectiveness-implementation study protocol.

Autor: Wagoner CW; Faculty of Kinesiology, University of Calgary, 2500 University Dr NW, T2N IN4, Calgary, Alberta, Canada. chad.wagoner@ucalgary.ca.; Ohlson Research Initiative, Arnie Charbonneau Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. chad.wagoner@ucalgary.ca.; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. chad.wagoner@ucalgary.ca., Daun JT; Faculty of Kinesiology, University of Calgary, 2500 University Dr NW, T2N IN4, Calgary, Alberta, Canada., Danyluk J; Faculty of Kinesiology, University of Calgary, 2500 University Dr NW, T2N IN4, Calgary, Alberta, Canada., Twomey R; Faculty of Kinesiology, University of Calgary, 2500 University Dr NW, T2N IN4, Calgary, Alberta, Canada., Murphy L; Physical Medicine & Rehabilitation, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Peterson M; Ohlson Research Initiative, Arnie Charbonneau Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Gentleman E; Faculty of Kinesiology, University of Calgary, 2500 University Dr NW, T2N IN4, Calgary, Alberta, Canada., Capozzi LC; Physical Medicine & Rehabilitation, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Francis GJ; Physical Medicine & Rehabilitation, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Chandarana SP; Ohlson Research Initiative, Arnie Charbonneau Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Surgery, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Hart RD; Ohlson Research Initiative, Arnie Charbonneau Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Surgery, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Matthews TW; Ohlson Research Initiative, Arnie Charbonneau Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Surgery, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., McKenzie D; Ohlson Research Initiative, Arnie Charbonneau Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Surgery, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Matthews J; Ohlson Research Initiative, Arnie Charbonneau Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Surgery, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Nakoneshny SC; Ohlson Research Initiative, Arnie Charbonneau Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada., Schrag C; Ohlson Research Initiative, Arnie Charbonneau Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Surgery, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Sauro KM; Ohlson Research Initiative, Arnie Charbonneau Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Surgery, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; O'Brien Institute of Public Health, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Dort JC; Ohlson Research Initiative, Arnie Charbonneau Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.; Department of Surgery, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Manaloto V; Acute Care, Alberta Health Services, Calgary, Canada., Burnett L; Acute Care, Alberta Health Services, Calgary, Canada., Chisholm A; Acute Care, Alberta Health Services, Calgary, Canada., Lau H; Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada., Culos-Reed SN; Faculty of Kinesiology, University of Calgary, 2500 University Dr NW, T2N IN4, Calgary, Alberta, Canada.; Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.; Department of Psychosocial Resources, Tom Baker Cancer Centre, Alberta Health Services, Calgary, AB, Canada.
Jazyk: angličtina
Zdroj: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2023 Nov 28; Vol. 31 (12), pp. 726. Date of Electronic Publication: 2023 Nov 28.
DOI: 10.1007/s00520-023-08164-w
Abstrakt: Head and neck cancer (HNC) treatment often consists of major surgery followed by adjuvant therapy, which can result in treatment-related side effects, decreased physical function, and diminished quality of life. Perioperative nutrition interventions and early mobilization improve recovery after HNC treatment. However, there are few studies on prehabilitation that include exercise within the HNC surgical care pathway. We have designed a multiphasic exercise prehabilitation intervention for HNC patients undergoing surgical resection with free flap reconstruction. We will use a hybrid effectiveness-implementation study design guided by the RE-AIM framework to address the following objectives: (1) to evaluate intervention benefits through physical function and patient-reported outcome assessments; (2) to determine the safety and feasibility of the prehabilitation intervention; (3) to evaluate the implementation of exercise within the HNC surgical care pathway; and (4) to establish a post-operative screening and referral pathway to exercise oncology resources. The results of this study will provide evidence for the benefits and costs of a multiphasic exercise prehabilitation intervention embedded within the HNC surgical care pathway. This paper describes the study protocol design, multiphasic exercise prehabilitation intervention, planned analyses, and dissemination of findings. Trial registration: https://clinicaltrials.gov/NCT04598087.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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