Long-Term Follow-Up of Patients with Conjunctival Lymphoma after Individualized Lens-Sparing Electron Radiotherapy: Results from a Longitudinal Study.

Autor: Hoffmann C; Department of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, Germany.; National Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, Germany., Ringbaek T; Department of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, Germany.; National Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, Germany.; Department of Radiotherapy, Medical Physics Section, University Hospital Essen, 45147 Essen, Germany., Eckstein A; National Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, Germany.; Department of Ophthalmology, West German Cancer Centre, University Hospital Essen, 45147 Essen, Germany., Deya W; Department of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, Germany.; National Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, Germany.; Department of Radiotherapy, Medical Physics Section, University Hospital Essen, 45147 Essen, Germany., Santiago A; Department of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, Germany.; National Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, Germany.; Department of Radiotherapy, Medical Physics Section, University Hospital Essen, 45147 Essen, Germany., Heintz M; Department of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, Germany.; National Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, Germany.; Department of Radiotherapy, Medical Physics Section, University Hospital Essen, 45147 Essen, Germany., Lübcke W; Department of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, Germany.; National Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, Germany.; Department of Radiotherapy, Medical Physics Section, University Hospital Essen, 45147 Essen, Germany., Indenkämpen F; Department of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, Germany.; Department of Radiotherapy, Medical Physics Section, University Hospital Essen, 45147 Essen, Germany., Sauerwein W; Department of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, Germany., Flühs A; Department of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, Germany.; Department of Radiotherapy, Medical Physics Section, University Hospital Essen, 45147 Essen, Germany., Le Guin C; National Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, Germany.; Department of Ophthalmology, West German Cancer Centre, University Hospital Essen, 45147 Essen, Germany., Huettmann A; National Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, Germany.; Department of Hematology, West German Cancer Centre, University Hospital Essen, 45147 Essen, Germany., von Tresckow J; National Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, Germany.; Department of Hematology, West German Cancer Centre, University Hospital Essen, 45147 Essen, Germany., Göricke S; National Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, Germany.; Institute for Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, 45147 Essen, Germany., Deuschl C; National Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, Germany.; Institute for Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, 45147 Essen, Germany., Moliavi S; Department of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, Germany.; National Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, Germany., Poettgen C; Department of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, Germany.; National Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, Germany., Gauler T; Department of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, Germany.; National Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, Germany., Guberina N; Department of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, Germany.; National Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, Germany., Johansson P; National Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, Germany.; Institute of Cell Biology (Cancer Research), Faculty of Medicine, University of Duisburg-Essen, 45147 Essen, Germany., Bechrakis N; National Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, Germany.; Department of Ophthalmology, West German Cancer Centre, University Hospital Essen, 45147 Essen, Germany., Stuschke M; Department of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, Germany.; National Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), Partner Site University Hospital Essen, 45147 Essen, Germany., Guberina M; Department of Radiotherapy, West German Cancer Centre, University Hospital Essen, 45147 Essen, Germany.; National Center for Tumor Diseases (NCT) West, Campus Essen, 45147 Essen, Germany.; German Cancer Consortium (DKTK), Partner Site University Hospital Essen, 45147 Essen, Germany.
Jazyk: angličtina
Zdroj: Cancers [Cancers (Basel)] 2023 Nov 15; Vol. 15 (22). Date of Electronic Publication: 2023 Nov 15.
DOI: 10.3390/cancers15225433
Abstrakt: Irradiation with electrons is the primary treatment regime for localized conjunctival low-grade lymphomas. However, radiation-induced cataracts are a major cause of treatment-related morbidity. This study investigates whether lens-sparing electron irradiation produces sufficient disease control rates while preventing cataract formation. All consecutive patients with strictly conjunctival, low-grade Ann Arbor stage IE lymphoma treated with superficial electron irradiation between 1999 and 2021 at our department were reviewed. A total of 56 patients with 65 treated eyes were enrolled with a median follow-up of 65 months. The median dose was 30.96 Gy. A lens-spearing technique featuring a hanging rod blocking the central beam axis was used in 89.2% of all cases. Cumulative incidences of 5- and 10-year infield recurrences were 4.3% and 14.6%, incidences of 5- and 10-year outfield progression were 10.4% and 13.4%. We used patients with involvement of retroorbital structures treated with whole-orbit photon irradiation without lens protection-of which we reported in a previous study-as a control group. The cumulative cataract incidence for patients treated with electrons and lens protection was significantly lower ( p = 0.005) when compared to patients irradiated without lens protection. Thus, electrons are an effective treatment option for conjunctival low-grade lymphomas. The presented lens-sparing technique effectively prevents cataract formation.
Databáze: MEDLINE
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