Is auditory processing measured by the N100 an endophenotype for psychosis? A family study and a meta-analysis.

Autor:	Wang B; Division of Psychiatry, University College London, London, UK.; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Otten LJ; Institute of Cognitive Neuroscience, University College London, London, UK., Schulze K; South London and Maudsley NHS Foundation Trust, London, UK., Afrah H; Division of Psychiatry, University College London, London, UK., Varney L; Division of Psychiatry, University College London, London, UK., Cotic M; Division of Psychiatry, University College London, London, UK.; Department of Genetics & Genomic Medicine, UCL Great Ormond Street Institute of Child Health, University College London, London, UK., Saadullah Khani N; Division of Psychiatry, University College London, London, UK., Linden JF; Ear Institute, University College London, London, UK.; Department of Neuroscience, Physiology & Pharmacology, University College London, London, UK., Kuchenbaecker K; Division of Psychiatry, University College London, London, UK.; Division of Biosciences, UCL Genetics Institute, University College London, London, UK., McQuillin A; Division of Psychiatry, University College London, London, UK., Hall MH; Psychosis Neurobiology Laboratory, Harvard Medical School, McLean Hospital, Belmont, MA, USA., Bramon E; Division of Psychiatry, University College London, London, UK.; Institute of Cognitive Neuroscience, University College London, London, UK.
Jazyk:	angličtina
Zdroj:	Psychological medicine [Psychol Med] 2024 Jun; Vol. 54 (8), pp. 1559-1572. Date of Electronic Publication: 2023 Nov 24.
DOI:	10.1017/S0033291723003409
Abstrakt:	Background: The N100, an early auditory event-related potential, has been found to be altered in patients with psychosis. However, it is unclear if the N100 is a psychosis endophenotype that is also altered in the relatives of patients. Methods: We conducted a family study using the auditory oddball paradigm to compare the N100 amplitude and latency across 243 patients with psychosis, 86 unaffected relatives, and 194 controls. We then conducted a systematic review and a random-effects meta-analysis pooling our results and 14 previously published family studies. We compared data from a total of 999 patients, 1192 relatives, and 1253 controls in order to investigate the evidence and degree of N100 differences. Results: In our family study, patients showed reduced N100 amplitudes and prolonged N100 latencies compared to controls, but no significant differences were found between unaffected relatives and controls. The meta-analysis revealed a significant reduction of the N100 amplitude and delay of the N100 latency in both patients with psychosis (standardized mean difference [s.m.d.] = -0.48 for N100 amplitude and s.m.d. = 0.43 for N100 latency) and their relatives (s.m.d. = - 0.19 for N100 amplitude and s.m.d. = 0.33 for N100 latency). However, only the N100 latency changes in relatives remained significant when excluding studies with affected relatives. Conclusions: N100 changes, especially prolonged N100 latencies, are present in both patients with psychosis and their relatives, making the N100 a promising endophenotype for psychosis. Such changes in the N100 may reflect changes in early auditory processing underlying the etiology of psychosis.
Databáze:	MEDLINE
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