Fine needle aspiration as a diagnostic modality for Warthin tumors identified as fluorodeoxyglucose positron emission tomography/computed tomography-positive.

Autor: Kowalewski A; Department of Pathology, Institut Curie, Paris, France.; Department of Clinical Pathomorphology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland., Tissot H; Department of Nuclear Medicine, Institut Curie, Paris, France., Jehanno N; Department of Nuclear Medicine, Institut Curie, Paris, France., Bakuła Zalewska E; Department of Pathology, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland., Choussy O; Department of Head and Neck Surgery, Institut Curie, Paris, France., Lesnik M; Department of Head and Neck Surgery, Institut Curie, Paris, France., Badois N; Department of Head and Neck Surgery, Institut Curie, Paris, France., Rougier G; Department of Head and Neck Surgery, Institut Curie, Paris, France., Klijanienko J; Department of Pathology, Institut Curie, Paris, France.
Jazyk: angličtina
Zdroj: Diagnostic cytopathology [Diagn Cytopathol] 2024 Feb; Vol. 52 (2), pp. 116-122. Date of Electronic Publication: 2023 Nov 22.
DOI: 10.1002/dc.25255
Abstrakt: Limited evidence exists regarding the 2-deoxy-2-[fluorine-18]-fluoro-D-glucose (FDG) avidity of Warthin tumors, the second most common benign parotid gland tumor. This study aims to clarify this aspect by analyzing patients who underwent FDG positron emission tomography/computed tomography (PET/CT) and quantifying tumor standardized uptake values (SUV). Medical records of 29 patients with fine needle aspiration (FNA)-confirmed Warthin tumors who underwent FDG-PET/CT near the diagnosis of Warthin tumor were reviewed. Key parameters included cancer history, cytologic diagnosis of Warthin tumor, maximum SUV on FDG PET/CT, and tumor localization. Among the cohort, 18 males and 11 females (average age: 67.9 years) were included. Most patients had malignant neoplasms (lung, head and neck, breast, others). One patient had synchronous liver cancer. Three individuals had bilateral Warthin tumors, and three had bifocal tumors, resulting in 35 tumors for analysis. Tumors were located in the parotid gland (28) and vicinity (7). SUVmax for the Warthin tumors ranged from 3.6 to 26.8, with an average SUVmax of 10.1. Warthin tumors exhibit significant and variable FDG accumulation, exceeding expectations and mimicking high-grade malignancies. Awareness of this phenomenon is crucial for accurate staging and timely management. In cases of positive FDG PET/CT uptake in periparotid, perimandibular, and upper jugular areas, FNA is recommended to avoid misinterpretation or delays in management.
(© 2023 Wiley Periodicals LLC.)
Databáze: MEDLINE
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