Botany, traditional usages, phytochemistry, pharmacology, and toxicology of Guilandina bonduc L.: a systematic review.

Autor: Srinivasan P; Division of Phytochemistry and Drug Design, Department of Biosciences, Rajagiri College of Social Sciences, Cochin, Kerala, 683 104, India. prabhusbotany@gmail.com., Karunanithi K; Department of Chemistry, Government College of Engineering, Sengipatti, Thanjavur, Tamil Nadu, 613 402, India., Muniappan A; PG and Research Department of Botany, AVVM Sri Pushpam College (Autonomous) Poondi, (Affiliated to Bharathidasan University), Tamil Nadu, Thanjavur, 613 503, India., Singamoorthy A; Division of Phytochemistry and Drug Design, Department of Biosciences, Rajagiri College of Social Sciences, Cochin, Kerala, 683 104, India., Kadaikunnan S; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, 11451, Saudi Arabia., Narayanan SP; Department of Microbiology, Cauvery College for Women, Annamalai Nagar, Trichy, Tamil Nadu, 620018, India., Thiruvengadam M; Department of Crop Science, College of Sanghuh Life Science, Konkuk University, Seoul, 05029, Korea., Nagamuthu P; Department of Chemistry, Annai Vailankanni Arts and Science College, Bishop Sundaram Campus, (Affiliated to Bharathidasan University), Thanjavur, Tamil Nadu, 613 007, India.
Jazyk: angličtina
Zdroj: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2024 May; Vol. 397 (5), pp. 2747-2775. Date of Electronic Publication: 2023 Nov 21.
DOI: 10.1007/s00210-023-02822-w
Abstrakt: Guilandina bonduc L. is popularly known as a fever nut that grows widely in evergreen forests and moist deciduous forests with a pantropical distribution. The plant is highly therapeutic in various systems of medicine, including Ayurveda, Siddha, and homeopathy. The purpose of this review is to analyze the published data on G. bonduc, including traditional uses, taxonomic position, botanical description, phytochemistry, pharmacological properties, and toxicological assessment of its various parts. Phytochemical and pharmacological studies were the main focus of this review. The previously published research on G. bonduc was tracked from scientific databases such as Online Library, Google, Taylor and Francis, PubMed, Research Gate, Scopus, Springer, Wiley, Web of Sciences. Numerous phytochemical, pharmaceutical, and pharmacological studies have been carried out on the various parts of G. bonduc. To date, more than 97 phytochemicals have been isolated from the leaves, roots, stems, stem bark, flowers, twigs, and seeds of this plant. The phytochemicals isolated from the plants are flavonoids, homoisoflavonoids, terpenoids, diterpenoids, steroids, fatty acids, alkanes, acids, phenols, ketones, esters, amides, azides, silanes, and ether groups. This plant has been extensively studied in in vitro and in vivo pharmacological experiments, where it showed analgesic, anti-inflammatory, antioxidant, antiviral, antidiabetic, abortive, anticataleptic, immunomodulatory, and antiestrogenic effects. This comprehensive review revealed that phytochemicals isolated from various parts of G. bonduc have significant therapeutic efficacy, with promising anticancer, antidiabetic, hepatoprotective, antioxidant, and antimicrobial activities. This review provides a good source of information for the development of a drug using modern scientific tools, in view of its underexplored traditional uses. Further studies on preclinical and clinical trials and toxicological studies on the bioactive molecules of G. bonduc to validate its traditional uses are warranted.
(© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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