Disuse-driven plasticity in the human thalamus and putamen.

Autor:	Chauvin RJ; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110., Newbold DJ; Department of Neurology, New York University Grossman School of Medicine, New York, New York 10016, USA., Nielsen AN; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110., Miller RL; Basque Center on Cognition, Brain and Language, Donostia, Gipuzkoa, Spain., Krimmel SR; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110., Metoki A; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110., Wang A; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.; Department of Biomedical Engineering, Washington University in St. Louis, MO 63130., Van AN; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.; Division of Computation and Data Science, Washington University School of Medicine, St. Louis, MO 63110., Montez DF; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110., Marek S; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110., Suljic V; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110., Baden NJ; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110., Ramirez-Perez N; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110., Scheidter KM; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110., Monk JS; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110., Whiting FI; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110., Adeyemo B; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110., Snyder AZ; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110., Kay BP; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110., Raichle ME; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110.; Department of Psychological and Brain Sciences, Washington University in St. Louis, St Louis, MO, USA.; Department of Neuroscience, Washington University School of Medicine, St Louis, MO, USA., Laumann TO; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110., Gordon EM; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110., Dosenbach NUF; Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110.; Department of Biomedical Engineering, Washington University in St. Louis, MO 63130.; Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2024 Jan 25. Date of Electronic Publication: 2024 Jan 25.
DOI:	10.1101/2023.11.07.566031
Abstrakt:	Motor adaptation in cortico-striato-thalamo-cortical loops has been studied mainly in animals using invasive electrophysiology. Here, we leverage functional neuroimaging in humans to study motor circuit plasticity in the human subcortex. We employed an experimental paradigm that combined two weeks of upper-extremity immobilization with daily resting-state and motor task fMRI before, during, and after the casting period. We previously showed that limb disuse leads to decreased functional connectivity (FC) of the contralateral somatomotor cortex (SM1) with the ipsilateral somatomotor cortex, increased FC with the cingulo-opercular network (CON) as well as the emergence of high amplitude, fMRI signal pulses localized in the contralateral SM1, supplementary motor area and the cerebellum. From our prior observations, it remains unclear whether the disuse plasticity affects the thalamus and striatum. We extended our analysis to include these subcortical regions and found that both exhibit strengthened cortical FC and spontaneous fMRI signal pulses induced by limb disuse. The dorsal posterior putamen and the central thalamus, mainly CM, VLP and VIM nuclei, showed disuse pulses and FC changes that lined up with fmri task activations from the Human connectome project motor system localizer, acquired before casting for each participant. Our findings provide a novel understanding of the role of the cortico-striato-thalamo-cortical loops in human motor plasticity and a potential link with the physiology of sleep regulation. Additionally, similarities with FC observation from Parkinson Disease (PD) questions a pathophysiological link with limb disuse. Competing Interests: Competing Interests A.N.V. and N.U.F.D. have a financial interest in Turing Medical Inc. and may benefit financially if the company is successful in marketing FIRMM motion monitoring software products. A.N.V. and N.U.F.D. may receive royalty income based on FIRMM technology developed at Washington University School of Medicine and Oregon Health and Sciences University and licensed to Turing Medical Inc. N.U.F.D. are co-founders of Turing Medical Inc. These potential conflicts of interest have been reviewed and are managed by Washington University School of Medicine, Oregon Health and Sciences University and the University of Minnesota. A.N.V. is now an employee of Turing Medical Inc. The other authors declare no competing interests.
Databáze:	MEDLINE
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