A Multicenter Retrospective Chart Review on the Effectiveness and Tolerability of Electroconvulsive Therapy in Adolescents and Young Adults With Major Depressive Disorder or Bipolar Depression.

Autor:	Schukking N; From the Department of Adult Psychiatry, Amsterdam UMC, University of Amsterdam., Scheepstra KWF, Bergfeld IO, van Waarde JA; Department of Psychiatry, Rijnstate Hospital, Arnhem., Tendolkar I; Department of Psychiatry, Donders Institute for Brain, Cognition, and Behavior, Nijmegen., Spaans HP; Department of Psychiatry, Parnassia Groep, Den Haag., Hegeman AJM; Department of Psychiatry, St. Antonius Ziekenhuis, Utrecht, the Netherlands., Scheepens DS, Lok A
Jazyk:	angličtina
Zdroj:	The journal of ECT [J ECT] 2024 Sep 01; Vol. 40 (3), pp. 145-153. Date of Electronic Publication: 2023 Nov 15.
DOI:	10.1097/YCT.0000000000000978
Abstrakt:	Background: Major depressive disorder and bipolar depression in adolescents and young adults are prevalent and major contributors to the global burden of disease, whereas effective interventions are limited. Available evidence is insufficient to assess effectiveness and tolerability of electroconvulsive therapy in depressed adolescents and young adults. Methods: A retrospective chart review was conducted in patients with major depressive disorder or bipolar depression who underwent electroconvulsive therapy from 2001 to 2021 in 12 centers in the Netherlands. Patients were classified as young (15-25 years) and older adults (26-80 years). Primary outcome was effectiveness, expressed as response (≥50% reduction in rating scale score compared with baseline) and remission. Rating scale scores were cross-sectionally assessed at baseline and at the end of the index course. Outcomes of remitters were included in responders. Secondary outcome was occurrence of subjective cognitive impairment and adverse events. Long-term outcomes were not available. Results: In the young (n = 57) and older adult (n = 41) group, 40.4% and 56.1% ( P = 0.153) of patients achieved response and 28.1% and 39.0% ( P = 0.281) remission, respectively. Subjective cognitive impairment (80.5% vs 56.3%; P = 0.001) and transient cardiac arrhythmia (14.6% vs 2.8%; P = 0.020) were reported significantly more frequently in the older adult group. Conclusions: Despite significantly more comorbidity of personality disorders, autism spectrum disorders, and anxiety disorders, effectiveness in the young was similar to the older adults. Tolerability was even superior in the young, despite significantly more bilateral treatment. Electroconvulsive therapy could be considered a viable treatment option in depressed adolescents and young adults. Competing Interests: The authors have no conflicts of interest or financial disclosures to report. This work was funded by the Amsterdam UMC Innovation grant 2017. (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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