Characterization of meiotic recombination intermediates through gene knockouts in founder hybrid mice.
Autor: | Davies B; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom.; The Francis Crick Institute, London NW1 1AT, United Kingdom., Zhang G; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom., Moralli D; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom., Alghadban S; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom., Biggs D; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom., Preece C; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom., Donnelly P; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom.; Genomics PLC, Oxford OX1 1JD, United Kingdom., Hinch AG; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, United Kingdom; anjali.hinch@well.ox.ac.uk. |
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Jazyk: | angličtina |
Zdroj: | Genome research [Genome Res] 2023 Dec 01; Vol. 33 (11), pp. 2018-2027. Date of Electronic Publication: 2023 Dec 01. |
DOI: | 10.1101/gr.278024.123 |
Abstrakt: | Mammalian meiotic recombination proceeds via repair of hundreds of programmed DNA double-strand breaks, which requires choreographed binding of RPA, DMC1, and RAD51 to single-stranded DNA substrates. High-resolution in vivo binding maps of these proteins provide insights into the underlying molecular mechanisms. When assayed in F (© 2023 Davies et al.; Published by Cold Spring Harbor Laboratory Press.) |
Databáze: | MEDLINE |
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