Prospective evaluation of liver shearwave elastography measurements with 3 different technologies and same day liver biopsy in patients with chronic liver disease.

Autor: Atzori SM; Liver Unit QEQM Wing St. Mary Hospital, Department of Surgery and Cancer, Imperial College London, South Wharf Road, London W1 1NY, United Kingdom; Department of Medicine, Sassari University Hospital, Via Enrico de Nicola, Sassari 07100, Italy. Electronic address: sebastiana_atzori@aouss.it., Pasha Y; Liver Unit QEQM Wing St. Mary Hospital, Department of Surgery and Cancer, Imperial College London, South Wharf Road, London W1 1NY, United Kingdom., Maurice JB; Liver Unit QEQM Wing St. Mary Hospital, Department of Surgery and Cancer, Imperial College London, South Wharf Road, London W1 1NY, United Kingdom; UCL Institute for Liver and Digestive Health, Royal Free Hospital Campus, London, Rowland Hill Street, NW3 2QG, United Kingdom., Taylor-Robinson SD; Liver Unit QEQM Wing St. Mary Hospital, Department of Surgery and Cancer, Imperial College London, South Wharf Road, London W1 1NY, United Kingdom., Campbell L; Liver Unit QEQM Wing St. Mary Hospital, Department of Surgery and Cancer, Imperial College London, South Wharf Road, London W1 1NY, United Kingdom; Office of the Clinical Director, Tawazun Health, 23 Harley Street, London W1G 9QN, United Kingdom., Lim AKP; Imaging Department, Charing Cross Hospital, Imperial College Healthcare NHS Trust, Fulham Palace Road, London W6 8RF, United Kingdom.
Jazyk: angličtina
Zdroj: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver [Dig Liver Dis] 2024 Mar; Vol. 56 (3), pp. 484-494. Date of Electronic Publication: 2023 Nov 14.
DOI: 10.1016/j.dld.2023.10.020
Abstrakt: Background: Most ultrasound-based methods for assessing liver fibrosis still need further validation with liver biopsy used as gold standard to assess their accuracy.
Aims: To assess accuracy of three shear wave elastography (SWE) methods: 1) Philips Elast Point Quantification (ElastPQ TM ), 2) Siemens Virtual Touch TM Quantification (VTQ) acoustic radiation force impulse (ARFI), and 3) transient elastography (TE) measured by Echosens Fibroscan TM .
Methods: 160 patients underwent liver stiffness measurements (LSM) with three SWE methods immediately prior to liver biopsy.
Results: The number of LSM required for reliable studies could be reduced to 6 for ElastPQ and to 7 for VTQ from standard recommendations of 10. Significant fibrosis and interquartile range/median (IQR/M)> 30 were independent predictors for lower reliability for detection of liver fibrosis. Ordinal logistic regression corrected for age showed that there was a significant interaction between steatosis (p = 0.008) and lobular inflammation (p = 0.04) and VTQ (ARFI) and between lobular inflammation and TE (p = 0.006).
Conclusions: We showed variations in SWE measurements using different ARFI technologies. TE and ElastPQ achieved good diagnostic performance, whereas VTQ showed lower diagnostic accuracy. The number of measurements required for reliable studies can be reduced to 6 for ElastPQ and to 7 for VTQ, which have important clinical implications.
Competing Interests: Conflict of interest The study was partially funded by an investigator-led grant from Philips Healthcare (Seattle, WA, USA) to Sebastiana Atzori and Adrian Lim (a Wellcome Trust Grant to Simon Taylor-Robinson also funded this study). Echosens (Paris, France), Philips Healthcare (Seattle, WA, USA) and Siemens (Berlin, Germany) provided the equipment used in the study, but none of the companies had input into the study design, its conduct or its interpretation, nor were they party to the unpublished results. The authors report no other conflicts of interest. The authors alone are responsible for the content and writing of this article. Authorship Statement: Guarantor of the article: Sebastiana Atzori and Adrian Lim Authors Contribution: Study concept and design: All authors Acquisition of data: Sebastiana Atzori and Louise Campbell Analysis and interpretation of data: All authors Statistical analysis: Sebastiana Atzori Drafting of the manuscript: Sebastiana Atzori Critical revision of the manuscript for important intellectual content: All authors Study supervision: Taylor-Robinson, Campbell, Lim All authors approved this version of the manuscript. All authors had full access to all the data in the study and take responsibility for the integrity of the data and accuracy of the data analysis.
(Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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