Effects of a laboratory-based aerobic exercise intervention on brain volume and cardiovascular health markers: protocol for a randomised clinical trial.

Autor:	Molina Hidalgo C; AdventHealth Research Institute, Neuroscience Institute, Orlando, Florida, USA cristina.molinahidalgo@adventhealth.com.; Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Collins AM; AdventHealth Research Institute, Neuroscience Institute, Orlando, Florida, USA.; Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Crisafio ME; College of Health and Human Sciences, Colorado State University, Fort Collins, Colorado, USA., Grove G; Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Kamarck TW; Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Kang C; Department of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Leckie RL; Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., MacDonald M; Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Manuck SB; Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Marsland AL; Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Muldoon MF; Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Rasero J; ExPhy Research group and Department of Physical Education, Faculty of Education Sciences, University of Cadiz, Cadiz, Spain., Scudder MR; Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Velazquez-Diaz D; AdventHealth Research Institute, Neuroscience Institute, Orlando, Florida, USA.; Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; ExPhy Research group and Department of Physical Education, Faculty of Education Sciences, University of Cadiz, Cadiz, Spain., Verstynen T; Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA., Wan L; Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Gianaros PJ; Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Erickson KI; AdventHealth Research Institute, Neuroscience Institute, Orlando, Florida, USA.; Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; PROFITH 'PROmoting FITness and Health Through Physical Activity' Research Group, Sport and Health University Research Institute (iMUDS), Department of Physical and Sports Education, Faculty of Sport Sciences, University of Granada, Granada, Spain.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2023 Nov 15; Vol. 13 (11), pp. e077905. Date of Electronic Publication: 2023 Nov 15.
DOI:	10.1136/bmjopen-2023-077905
Abstrakt:	Introduction: Physical activity (PA) has beneficial effects on brain health and cardiovascular disease (CVD) risk. Yet, we know little about whether PA-induced changes to physiological mediators of CVD risk influence brain health and whether benefits to brain health may also explain PA-induced improvements to CVD risk. This study combines neurobiological and peripheral physiological methods in the context of a randomised clinical trial to better understand the links between exercise, brain health and CVD risk. Methods and Analysis: In this 12-month trial, 130 healthy individuals between the ages of 26 and 58 will be randomly assigned to either: (1) moderate-intensity aerobic PA for 150 min/week or (2) a health information control group. Cardiovascular, neuroimaging and PA measurements will occur for both groups before and after the intervention. Primary outcomes include changes in (1) brain structural areas (ie, hippocampal volume); (2) systolic blood pressure (SBP) responses to functional MRI cognitive stressor tasks and (3) heart rate variability. The main secondary outcomes include changes in (1) brain activity, resting state connectivity, cortical thickness and cortical volume; (2) daily life SBP stress reactivity; (3) negative and positive affect; (4) baroreflex sensitivity; (5) pulse wave velocity; (6) endothelial function and (7) daily life positive and negative affect. Our results are expected to have both mechanistic and public health implications regarding brain-body interactions in the context of cardiovascular health. Ethics and Dissemination: Ethical approval has been obtained from the University of Pittsburgh Institutional Review Board (IRB ID: 19020218). This study will comply with the NIH Data Sharing Policy and Policy on the Dissemination of NIH-Funded Clinical Trial Information and the Clinical Trials Registration and Results Information Submission rule. Trial Registration Number: NCT03841669. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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