Pathological claustrum activity drives aberrant cognitive network processing in human chronic pain.

Autor:	Stewart BW; Department of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA., Keaser ML; Department of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA., Lee H; Department of Epidemiology & Public Health, Maryland Psychiatric Research Center, Catonsville, MD, USA., Margerison SM; Department of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA.; Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore, MD, USA., Cormie MA; Centre for Multimodal Sensorimotor and Pain Research, Faculty of Dentistry, University of Toronto, ON, Canada., Moayedi M; Centre for Multimodal Sensorimotor and Pain Research, Faculty of Dentistry, University of Toronto, ON, Canada.; Department of Dentistry, Mount Sinai Hospital, Toronto, ON, Canada.; Division of Clinical & Computational Neuroscience, Krembil Brain Institute, University Health Network., Lindquist MA; Department of Biostatistics, Johns Hopkins University, Baltimore, MD, USA., Chen S; Department of Epidemiology & Public Health, Maryland Psychiatric Research Center, Catonsville, MD, USA., Mathur BN; Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, USA., Seminowicz DA; Department of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, MD, USA.; Department of Medical Biophysics, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 02. Date of Electronic Publication: 2023 Nov 02.
DOI:	10.1101/2023.11.01.564054
Abstrakt:	Aberrant cognitive network activity and cognitive deficits are established features of chronic pain. However, the nature of cognitive network alterations associated with chronic pain and their underlying mechanisms require elucidation. Here, we report that the claustrum, a subcortical nucleus implicated in cognitive network modulation, is activated by acute painful stimulation and pain-predictive cues in healthy participants. Moreover, we discover pathological activity of the claustrum and a lateral aspect of the right dorsolateral prefrontal cortex (latDLPFC) in migraine patients. Dynamic causal modeling suggests a directional influence of the claustrum on activity in this latDLPFC region, and diffusion weighted imaging (DWI) verifies their structural connectivity. These findings advance understanding of claustrum function during acute pain and provide evidence of a possible circuit mechanism driving cognitive impairments in chronic pain. Competing Interests: Declaration of Interests: The authors declare no competing interests.
Databáze:	MEDLINE
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