[Familial aggregation in Irritable Colon Syndrome in Mexican patients. A case-control study].

Autor:	Ramírez Aranda JM; Departamento de Medicina Familiar, UANL, Monterrey, México. Electronic address: sersabe2010@gmail.com., Martínez Gutiérrez CM; Departamento de Medicina Familiar, UANL, Monterrey, México., Fuentes Ramírez MM; Facultad de Medicina, UANL, Monterrey, México., Escobedo Ríos MR; Facultad de Medicina, UANL, Monterrey, México., Delgado Cuevas FDR; UMF 10, Instituto Mexicano del Seguro Social, San Luis Potosí, México.
Jazyk:	Spanish; Castilian
Zdroj:	Atencion primaria [Aten Primaria] 2024 Feb; Vol. 56 (2), pp. 102794. Date of Electronic Publication: 2023 Nov 09.
DOI:	10.1016/j.aprim.2023.102794
Abstrakt:	Objective: To determine a family aggregation pattern of Irritable Bowel Syndrome (IBS). Design: it is a case-control study with a 1.2 ratio. Setting: External consultation of a general family medicine practice. Participants: men and women from 18 to 60 years old. Cases (40): people with IBS according to the Rome IV criteria, and Controls (80): relatives without gastrointestinal disease. Main Measurements: Sociodemographic variables, related stressful events, predominant evacuation patterns, and family repetition patterns for IBS. Data were analyzed with descriptive and inferential statistics. Chi-square for categorical data (< p.05 as significant) estimate of ORs with 95% confidence interval. The institutional ethics committee approved it. Results: The IBS presentation pattern was repeated in relatives, mainly first-degree. The risk of suffering from IBS was higher when the father reported it (OR 11.2 (95% CI; 1.2 -100.1), than the mother OR 3,7 (95% CI; 1.4 - 9.9), sibling OR 2.8 (95% CI; 1.1 - 6.6. In both groups, the relative who most frequently presented IBS was in the collateral line (sibling) (37.5% in cases vs. 17.5% in controls (p=0.023). In both groups, the predominant gender was female, with 80. 0% in cases and 57.5% in controls. Conclusion: SII has a familial recurrence pattern in the Mexican population. The disease is more frequent in first-degree relatives. It is important to elucidate the importance of the role that plays genetic background vs. the influence of the family environment in SII. (Copyright © 2023 The Authors. Publicado por Elsevier España, S.L.U. All rights reserved.)
Databáze:	MEDLINE
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