Update on the ethical, legal and technical challenges of translating xenotransplantation.

Autor:	Thom R; Department of Nephrology and Transplantation, Guy's and St Thomas' Hospitals NHS Trust, London, UK., Ayares D; Revivicor Inc, Blacksburg, Virginia, USA., Cooper DKC; Centre for Transplantation Sciences, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA., Dark J; Newcastle University Faculty of Medical Sciences, Newcastle upon Tyne, Newcastle upon Tyne, UK., Fovargue S; School of Law, The University of Sheffield, Sheffield, UK., Fox M; School of Law and Social Justice at the University of Liverpool, Liverpool, Merseyside, UK., Gusmano M; Community and Population Health, Lehigh University, Bethlehem, Pennsylvania, USA., Locke J; Division of Transplantation, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA., McGregor C; Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA., Parent B; Medical Ethics, New York University School of Medicine, New York, New York, USA., Ravanan R; Southmead Hospital, Bristol, UK., Shaw D; Institute for Biomedical Ethics, University of Basel, Basel, Switzerland., Dorling A; Department of Nephrology and Transplantation, Guy's and St Thomas' Hospitals NHS Trust, London, UK.; Centre for Nephrology, Urology and Transplantation, King's College, London, UK., Cronin AJ; Department of Nephrology and Transplantation, Guy's and St Thomas' Hospitals NHS Trust, London, UK antonia.cronin@kcl.ac.uk.; Centre for Nephrology, Urology and Transplantation, King's College, London, UK.
Jazyk:	angličtina
Zdroj:	Journal of medical ethics [J Med Ethics] 2024 Aug 21; Vol. 50 (9), pp. 585-591. Date of Electronic Publication: 2024 Aug 21.
DOI:	10.1136/jme-2023-109298
Abstrakt:	This manuscript reports on a landmark symposium on the ethical, legal and technical challenges of xenotransplantation in the UK. King's College London, with endorsement from the British Transplantation Society (BTS), and the European Society of Organ Transplantation (ESOT), brought together a group of experts in xenotransplantation science, ethics and law to discuss the ethical, regulatory and technical challenges surrounding translating xenotransplantation into the clinical setting. The symposium was the first of its kind in the UK for 20 years. This paper summarises the content of the expert lectures showcasing the progress which has been made in xenotransplantation including-the history of xenotransplantation, advances in gene edited animals and progress towards clinical xenotransplantation. We then set out the ethical and legal issues still to be resolved. Finally, we report the themes of the roundtable discussion highlighting areas of consensus and controversy. While the detail of the legal discussion was directed towards the UK, the principles and summary reported here are intended to be applicable to any jurisdiction seeking to implement clinical xenotransplantation. Competing Interests: Competing interests: David Ayares is the chief scientific officer of Revivicor, Inc. David Cooper Consultant to eGenesis Bio, Cambridge, MA, USA. Jayme Locke receives grant salary support from Lung Biotechnology PBC, a subsidiary of United Therapeutics. (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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