Multicystic Clear Cell Renal Tumors With Low-grade Nuclear Features: Time to Include TFE3 Translocation-associated Carcinomas.
| Autor: | Cai Q; Departments of Pathology., Gagan J; Departments of Pathology., Koduru P; Departments of Pathology., Cadeddu J; Urology.; Kidney Cancer Program, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX., Shah RB; Departments of Pathology., Kapur P; Departments of Pathology.; Urology.; Kidney Cancer Program, Simmons Comprehensive Cancer Center, The University of Texas Southwestern Medical Center, Dallas, TX., Palsgrove DN; Departments of Pathology. |
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| Jazyk: | angličtina |
| Zdroj: | Advances in anatomic pathology [Adv Anat Pathol] 2024 Jan 01; Vol. 31 (1), pp. 34-42. Date of Electronic Publication: 2023 Nov 06. |
| DOI: | 10.1097/PAP.0000000000000420 |
| Abstrakt: | TFE3 -rearranged renal cell carcinoma (RCC) is a distinct, uncommon entity with more than 20 different fusion partners identified; however, histomorphology may be suggestive of specific fusion partners in select TFE3 -rearranged RCCs. For example, most MED15 :: TFE3 fusion associated RCCs exhibit multilocular cystic morphology, mimicking multilocular cystic renal neoplasm of low malignant potential. Here we present a case of MED15 :: TFE3 RCC in an older adult and review the literature with an emphasis on practical diagnostic approaches for predominantly cystic, low-grade, clear cell renal tumors. Competing Interests: The authors have no funding or conflicts of interest to disclose. (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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