| Autor: |
Gadde KM; Department of Surgery University of California, Irvine (UCI) Medical Center Orange CA., Yin X; Department of Biostatistics and Bioinformatics George Washington University Biostatistics Center Rockville MD., Goldberg RB; Diabetes Research Institute, University of Miami Miller School of Medicine Miami FL., Orchard TJ; University of Pittsburgh School of Public Health Pittsburgh PA., Schlögl M; Division of Geriatric Medicine, Clinic Barmelweid Barmelweid Switzerland., Dabelea D; Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center University of Colorado Anschutz Medical Campus Aurora CO., Ibebuogu UN; Department of Medicine University of Tennessee Health Science Center Memphis TN., Watson KE; Department of Medicine, David Geffen School of Medicine at UCLA Los Angeles CA., Pi-Sunyer FX; Department of Medicine Columbia University Irving Medical Center New York NY., Crandall JP; Department of Medicine, Albert Einstein College of Medicine Bronx NY., Temprosa M; Department of Biostatistics and Bioinformatics George Washington University Biostatistics Center Rockville MD., Luchsinger JA; Departments of Medicine and Epidemiology Columbia University New York NY. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of the American Heart Association [J Am Heart Assoc] 2023 Nov 07; Vol. 12 (21), pp. e029671. Date of Electronic Publication: 2023 Nov 06. |
| DOI: |
10.1161/JAHA.123.029671 |
| Abstrakt: |
Background Our aim was to investigate the association of coronary artery calcium (CAC) with cognitive function in adults with impaired glucose tolerance or type 2 diabetes. Methods and Results The Diabetes Prevention Program was a randomized controlled trial comparing an intensive lifestyle intervention, metformin, or placebo for prevention of type 2 diabetes among patients with prediabetes. After 3 years, intensive lifestyle intervention and placebo were stopped, the metformin arm was unmasked, and participants continued in the DPPOS (Diabetes Prevention Program Outcomes Study). Approximately 14 years after randomization (Y14), CAC (Agatston score) was assessed with computed tomography, and cognitive performance was assessed with the Spanish English Verbal Learning Test (SEVLT) and Digit Symbol Substitution Test. SEVLT and Digit Symbol Substitution Test were reassessed 5 years later (Y19) along with the Modified Mini-Mental State Exam. We examined cross-sectional and longitudinal associations between CAC and cognition among 1931 participants using linear and logistic regression. In unadjusted analyses, compared with no calcification, CAC score >300 was associated with decreased performance on all cognitive tests at Y14 in both sexes. Additionally, CAC >300 was associated with a greater 5-year decline in SEVLT Immediate Recall in both sexes and SEVLT Delayed Recall in women. After adjustment for demographic, genetic, metabolic, vascular, and behavioral covariates, CAC score >300 remained associated with greater decline in only SEVLT Delayed Recall in women. Conclusions In women with prediabetes or diabetes, CAC >300, compared with no calcification, was independently associated with greater decline in verbal memory. Registration information clinicaltrials.gov. Identifier: NCT00038727. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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