Perinatal asphyxia and hypothermic treatment from the endocrine perspective.

Autor:	Improda N; Department of Translational Medical Sciences, Paediatric Endocrinology Unit, University 'Federico II', Naples, Italy.; Department of Emergency, Santobono-Pausilipon Children's Hospital, Naples, Italy., Capalbo D; Department of Mother and Child, Paediatric Endocrinology Unit, University Hospital 'Federico II', Naples, Italy., Poloniato A; Neonatal Intensive Care Unit, San Raffaele University Hospital, Milan, Italy., Garbetta G; Neonatal Intensive Care Unit, San Raffaele University Hospital, Milan, Italy., Dituri F; Pediatric and Neonatal Unit, San Paolo Hospital, Civitavecchia, Italy., Penta L; Department of Pediatrics, University of Perugia, Perugia, Italy., Aversa T; Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy., Sessa L; Maternal and Child Department, Neonatal Intensive Care Unit (NICU) of University Hospital San Giovanni di Dio e Ruggi d'Aragona, Salerno, Italy., Vierucci F; Pediatric Unit, San Luca Hospital, Lucca, Italy., Cozzolino M; Department of Pediatrics, Santa Maria Delle Croci Hospital, Ravenna, Italy., Vigone MC; Endocrine Unit, Department of Pediatrics, University Hospital San Raffaele, Milan, Italy., Tronconi GM; Neonatal Intensive Care Unit, San Raffaele University Hospital, Milan, Italy., Del Pistoia M; Division of Neonatology and Neonatal Intensive Care Unit (NICU), Department of Clinical and Experimental Medicine, Santa Chiara University Hospital, Pisa, Italy., Lucaccioni L; Pediatric Unit, Department of Medical and Surgical Sciences of the Mother, Children and Adults, University of Modena and Reggio Emilia, Modena, Italy., Tuli G; Pediatric Endocrinology Unit, Regina Margherita Children's Hospital, Turin, Italy.; Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy., Munarin J; Pediatric Endocrinology Unit, Regina Margherita Children's Hospital, Turin, Italy.; Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy., Tessaris D; Pediatric Endocrinology Unit, Regina Margherita Children's Hospital, Turin, Italy.; Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy., de Sanctis L; Pediatric Endocrinology Unit, Regina Margherita Children's Hospital, Turin, Italy.; Department of Public Health and Pediatric Sciences, University of Turin, Turin, Italy., Salerno M; Department of Translational Medical Sciences, Paediatric Endocrinology Unit, University 'Federico II', Naples, Italy.
Jazyk:	angličtina
Zdroj:	Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2023 Oct 20; Vol. 14, pp. 1249700. Date of Electronic Publication: 2023 Oct 20 (Print Publication: 2023).
DOI:	10.3389/fendo.2023.1249700
Abstrakt:	Introduction: Perinatal asphyxia is one of the three most important causes of neonatal mortality and morbidity. Therapeutic hypothermia represents the standard treatment for infants with moderate-severe perinatal asphyxia, resulting in reduction in the mortality and major neurodevelopmental disability. So far, data in the literature focusing on the endocrine aspects of both asphyxia and hypothermia treatment at birth are scanty, and many aspects are still debated. Aim of this narrative review is to summarize the current knowledge regarding the short- and long-term effects of perinatal asphyxia and of hypothermia treatment on the endocrine system, thus providing suggestions for improving the management of asphyxiated children. Results: Involvement of the endocrine system (especially glucose and electrolyte disturbances, adrenal hemorrhage, non-thyroidal illness syndrome) can occur in a variable percentage of subjects with perinatal asphyxia, potentially affecting mortality as well as neurological outcome. Hypothermia may also affect endocrine homeostasis, leading to a decreased incidence of hypocalcemia and an increased risk of dilutional hyponatremia and hypercalcemia. Conclusions: Metabolic abnormalities in the context of perinatal asphyxia are important modifiable factors that may be associated with a worse outcome. Therefore, clinicians should be aware of the possible occurrence of endocrine complication, in order to establish appropriate screening protocols and allow timely treatment. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Improda, Capalbo, Poloniato, Garbetta, Dituri, Penta, Aversa, Sessa, Vierucci, Cozzolino, Vigone, Tronconi, del Pistoia, Lucaccioni, Tuli, Munarin, Tessaris, de Sanctis and Salerno.)
Databáze:	MEDLINE
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