Immune cells are associated with mortality: the Health and Retirement Study.

Autor:	Seshadri G; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, United States., Vivek S; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, United States., Prizment A; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, United States., Crimmins EM; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States., Klopack ET; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States., Faul J; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, United States., Guan W; Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, United States., Meier HCS; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, United States., Thyagarajan B; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, United States.; Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2023 Oct 20; Vol. 14, pp. 1280144. Date of Electronic Publication: 2023 Oct 20 (Print Publication: 2023).
DOI:	10.3389/fimmu.2023.1280144
Abstrakt:	Introduction: Age-related immunosenescence is characterized by changes in immune cell subsets and is associated with mortality. However, since immunosenescence is associated with other concurrent age-related changes such as inflammation and multi-organ dysfunction, it is unclear whether the association between age-related immunosenescence and mortality is independent of other concurrent age-related changes. To address these limitations, we evaluated the independent association between immune cell subsets and mortality after adjustment for age-related inflammation and biologic age. Methods: Data for this study was obtained from the 2016 interview of the Health and Retirement Study (N=6802). Cox proportional hazards regression models were used to estimate the association between 25 immune cell subsets (11 T-cell subsets, 4 B-cell subsets, 3 monocyte subsets, 3 natural killer cell subsets, 3 dendritic cell subsets, and neutrophils) and 4-year mortality adjusting for covariates such as the Klemera-Doubal algorithm biological age, chronological age, gender, race/ethnicity, BMI, smoking status, comorbidity index, CMV seropositivity, and inflammatory latent variable comprising C-reactive protein, and 4 cytokines (interleukin-10, interleukin-1 receptor antagonist, interleukin-6, and soluble tumor necrosis factor). Results: Four hundred and seventy-six participants died during the study period with an overall median follow up time of 2.5 years. After controlling for covariates and adjustment for sample-weights, total T cells [HR: 0.86, p=0.004], NK CD56LO cells [HR: 0.88, p=0.005], and neutrophils [HR: 1.22, p=0.004] were significantly associated with mortality. Conclusions: These findings support the idea that an aging immune system is associated with short-term mortality independent of age-related inflammation or other age-related measures of physiological dysfunction. If replicated in other external cohorts, these findings could identify novel targets for both monitoring and intervention to reduce the age-related mortality. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Seshadri, Vivek, Prizment, Crimmins, Klopack, Faul, Guan, Meier and Thyagarajan.)
Databáze:	MEDLINE
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