Transfusion transmissible infections among blood donors in Ghana: A 3-year multicentered health facility-based retrospective study.

Autor: Walana W; Department of Clinical Microbiology School of Medicine, University for Development Studies Tamale Ghana., Vicar EK; Department of Clinical Microbiology School of Medicine, University for Development Studies Tamale Ghana., Kuugbee ED; Department of Microbiology and Immunology School of Medicine and Dentistry Navrongo Ghana., Dari I; Community Health and Preventive Medicine School of Medicine, University for Development Studies Tamale Ghana., Bichenlib G; Community Health and Preventive Medicine School of Medicine, University for Development Studies Tamale Ghana., Aneba CN; Community Health and Preventive Medicine School of Medicine, University for Development Studies Tamale Ghana., Hinneh KN; Community Health and Preventive Medicine School of Medicine, University for Development Studies Tamale Ghana., Yabasin IB; Department of Anaesthesiology and Intensive Care University for Development Studies Tamale Ghana., Issaka KN; Department of Laboratory Service Wa Municipal Hospital, Upper West Region Wa Ghana., Danso MO; Department of Laboratory Service Weija-Gbawe Municipal Hospital, Greater Accra Region Accra Ghana., Amoatey TN; Nkwanta South Municipal Hospital, Oti Region Nkwantah Ghana., Ziem JB; Department of Microbiology and Immunology School of Medicine and Dentistry Navrongo Ghana.
Jazyk: angličtina
Zdroj: Health science reports [Health Sci Rep] 2023 Nov 01; Vol. 6 (11), pp. e1681. Date of Electronic Publication: 2023 Nov 01 (Print Publication: 2023).
DOI: 10.1002/hsr2.1681
Abstrakt: Transfusion transmissible infections (TTIs) remain a major health challenge particularly in developing countries. Here, we present a multicentered hospital-based retrospective study on the prevalence, distribution, and risk factors of TTIs in Ghana. Data on blood donors from four health facilities, namely Nkwanta South Municipal Hospital (Oti region), Weija-Gbawe Municipal Hospital (Greater Accra region), SDA Hospital (Northern region) and Wa Municipal Hospital (Upper West region) were extracted and analyzed. Descriptive statistics and multinomial logistic regression were applied to compare sociodemographic data with TTI status. A total of 6094 blood donors were included in this study, and 2% were females. The overall prevalence of TTIs was 21.0% (1232/5868). Specifically, the prevalence of HBV, HCV, HIV, and Syphilis was 6.6% (385/5868), 4.9% (286/5830), 2.9% (168/5867), and 6.8% (393/5739), respectively. Wa dominated in all the viral agents considered in this study, while the Oti region recorded the highest prevalence in T. pallidum . The odds of HBV infection was 3.1 ( p  = 0.008) among first-time donors, while that for HCV was 2.8 ( p  = 0.042). For rural dwellers, donors significantly had T. pallidum ( p  < 0.001; OR = 2.8), HCV ( p  < 0.001; OR = 2.9), and HIV ( p  = 0.028; OR = 1.5) infections. Generally, the recipients of transfused blood were predominantly pregnant mothers, followed by children and accident victims. This study has revealed significant disparities and relatively high prevalence of TTIs in Ghana, specifically HBV, HCV, HIV and T. pallidum infections. The variations suggest the presence of unique health challenges per study area, hence the need for a tailored intervention for each study site.
Competing Interests: The authors declare no conflict of interest.
(© 2023 The Authors. Health Science Reports published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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