Plasma essential fatty acid on hospital admission is a marker of COVID-19 disease severity.

Autor: Mazurak VC; Division of Human Nutrition, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, T6G 2P5, Canada., Rivas-Serna IM; Division of Human Nutrition, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, T6G 2P5, Canada., Parsons SR; Division of Human Nutrition, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, T6G 2P5, Canada., Monirujjaman M; Division of Human Nutrition, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, T6G 2P5, Canada., Maybank KE; Division of Human Nutrition, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, T6G 2P5, Canada., Woo SK; Division of Human Nutrition, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, T6G 2P5, Canada., Rewa OG; Department of Critical Care Medicine, Faculty of Medicine, University of Alberta, Edmonton, Canada., Cave AJ; Department of Family Medicine, University of Alberta, Edmonton, T6G 2P5, Canada., Richard C; Division of Human Nutrition, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, T6G 2P5, Canada., Clandinin MT; Division of Human Nutrition, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, T6G 2P5, Canada. clandinintom@gmail.com.; Department of Medicine, University of Alberta, Edmonton, T6G 2P5, Canada. clandinintom@gmail.com.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2023 Nov 03; Vol. 13 (1), pp. 18973. Date of Electronic Publication: 2023 Nov 03.
DOI: 10.1038/s41598-023-46247-0
Abstrakt: It is important for allocation of resources to predict those COVID patients at high risk of dying or organ failure. Early signals to initiate cellular events of host immunity can be derived from essential fatty acid metabolites preceding the cascade of proinflammatory signals. Much research has focused on understanding later proinflammatory responses. We assessed if remodelling of plasma phospholipid content of essential fatty acids by the COVID-19 virus provides early markers for potential death and disease severity. Here we show that, at hospital admission, COVID-19 infected subjects who survive exhibit higher proportions of C20:4n-6 in plasma phospholipids concurrent with marked proinflammatory cytokine elevation in plasma compared to healthy subjects. In contrast, more than half of subjects who die of this virus exhibit very low C18:2n-6 and C20:4n-6 content in plasma phospholipids on hospital admission compared with healthy control subjects. Moreover, in these subjects who die, the low level of primary inflammatory signals indicates limited or aberrant stimulation of host immunity. We conclude that COVID-19 infection results in early fundamental remodelling of essential fatty acid metabolism. In subjects with high mortality, it appears that plasma n-6 fatty acid content is too low to stimulate cellular events of host immunity.
(© 2023. The Author(s).)
Databáze: MEDLINE
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