MTSS1 is downregulated in nasopharyngeal carcinoma (NPC) which disrupts adherens junctions leading to enhanced cell migration and invasion.

Autor:	Zheng S; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.; ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China., Wang X; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Matskova L; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Zhou X; Scientific Research Centre, Life Science Institute, Guangxi Medical University, Nanning, China., Zhang Z; Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, China., Kashuba E; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.; RE Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology of National Academy of Sciences of Ukraine, Kyiv, Ukraine., Ernberg I; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden., Aspenström P; Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.; Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Jazyk:	angličtina
Zdroj:	Frontiers in cell and developmental biology [Front Cell Dev Biol] 2023 Oct 18; Vol. 11, pp. 1275668. Date of Electronic Publication: 2023 Oct 18 (Print Publication: 2023).
DOI:	10.3389/fcell.2023.1275668
Abstrakt:	Loss of cell-cell adhesions is the indispensable first step for cancer cells to depart from the primary tumor mass to metastasize. Metastasis suppressor 1 (MTSS1) is frequently lost in metastatic tissues, correlating to advanced tumor stages and poor prognosis across a variety of cancers. Here we explore the anti-metastatic mechanisms of MTSS1, which have not been well understood. We found that MTSS1 is downregulated in NPC tissues. Lower levels of MTSS1 expression correlate to worse prognosis. We show that MTSS1 suppresses NPC cell migration and invasion in vitro through cytoskeletal remodeling at cell-cell borders and assembly of E-cadherin/β-catenin/F-actin in adherens junctions. The I-BAR domain of MTSS1 was both necessary and sufficient to restore this formation of E-cadherin/β-catenin/F-actin-mediated cell adherens junctions. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Zheng, Wang, Matskova, Zhou, Zhang, Kashuba, Ernberg and Aspenström.)
Databáze:	MEDLINE
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