A decade in focus: mixed germ cell tumors with choriocarcinoma components.

Autor:	Al-Khayal A; Department of Urology, King Abdulaziz Medical City.; College of Medicine, King Saud bin Abdulaziz University for Health Sciences.; King Abdullah International Medical Research Center., Noureldin Y; Department of Urology, King Abdulaziz Medical City., Alghafees M; College of Medicine, King Saud bin Abdulaziz University for Health Sciences., Shafqat A; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia., Sabbah BN; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia., Elhossiny AH; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia., Bakir M; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia., Omar MA; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia., Arabi TZ; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia., Abdul Rab S; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia., Alsaikhan B; Department of Urology, King Abdulaziz Medical City.; College of Medicine, King Saud bin Abdulaziz University for Health Sciences.; King Abdullah International Medical Research Center., Aldhalaan R; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia., Alquirnas M; College of Medicine, King Saud bin Abdulaziz University for Health Sciences., Alrabeeah K; Department of Urology, King Abdulaziz Medical City.; College of Medicine, King Saud bin Abdulaziz University for Health Sciences.; King Abdullah International Medical Research Center.
Jazyk:	angličtina
Zdroj:	Annals of medicine and surgery (2012) [Ann Med Surg (Lond)] 2023 Sep 20; Vol. 85 (11), pp. 5355-5358. Date of Electronic Publication: 2023 Sep 20 (Print Publication: 2023).
DOI:	10.1097/MS9.0000000000001314
Abstrakt:	Introduction: This 10-year registry review aimed to investigate the clinical behaviour and outcomes of mixed germ cell tumours with choriocarcinoma components, a rare and aggressive subtype of testicular cancer, in Saudi Arabia. The study explores the demographic characteristics of affected patients, tumour profiles, and the mortality rate associated with this malignancy. Methods: Utilizing data from the Saudi Cancer Registry, the authors identified 33 cases of mixed germ cell tumours with choriocarcinoma components among 1001 testicular cancer cases recorded between 2008 and 2017. Demographic information, including age, marital status, region of residency, year of diagnosis, and 10-year survival status, were collected. Tumour factors, such as the basis of diagnosis, origin site, behaviour, grade, extension, and laterality, were also analyzed. Results: The majority of cases (78.8%) occurred in the young age group (18-45 years), and most tumours (97%) originated in normally descended testes. Grade IV (undifferentiated anaplastic) tumours and distant metastasis were present in 45.5% of patients. All cases exhibited malignant tumour behaviour. The overall mortality rate was 15%, with a mean time from diagnosis to death of 7.72 months (range: 0.5-21.5 months). Conclusion: Mixed germ cell tumours with choriocarcinoma components are rare and tend to affect younger populations. These tumours demonstrate aggressive clinical behaviour, with a significant proportion presenting with high-grade lesions and metastasis at diagnosis. The observed mortality rate underscores the poor prognosis associated with this malignancy. Our study provides essential insights into the clinical characteristics of this rare tumour subtype in the Saudi Arabian population, emphasizing the need for further research to identify prognostic factors and optimize management strategies for affected patients. Competing Interests: The authors declare that there are no conflicts of interest. (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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