Alterations of neural activity in the prefrontal cortex associated with deficits in working memory performance.

Autor:	Li S; Department of Neurobiology, The University of Chicago, Chicago, IL, United States., Rosen MC; Department of Neurobiology, The University of Chicago, Chicago, IL, United States., Chang S; Department of Neurobiology, The University of Chicago, Chicago, IL, United States., David S; Department of Neurobiology, The University of Chicago, Chicago, IL, United States., Freedman DJ; Department of Neurobiology, The University of Chicago, Chicago, IL, United States.; Neuroscience Institute, The University of Chicago, Chicago, IL, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in behavioral neuroscience [Front Behav Neurosci] 2023 Oct 17; Vol. 17, pp. 1213435. Date of Electronic Publication: 2023 Oct 17 (Print Publication: 2023).
DOI:	10.3389/fnbeh.2023.1213435
Abstrakt:	Working memory (WM), a core cognitive function, enables the temporary holding and manipulation of information in mind to support ongoing behavior. Neurophysiological recordings conducted in nonhuman primates have revealed neural correlates of this process in a network of higher-order cortical regions, particularly the prefrontal cortex (PFC). Here, we review the circuit mechanisms and functional importance of WM-related activity in these areas. Recent neurophysiological data indicates that the absence of these neural correlates at different stages of WM is accompanied by distinct behavioral deficits, which are characteristic of various disease states/normal aging and which we review here. Finally, we discuss emerging evidence of electrical stimulation ameliorating these WM deficits in both humans and non-human primates. These results are important for a basic understanding of the neural mechanisms supporting WM, as well as for translational efforts to developing therapies capable of enhancing healthy WM ability or restoring WM from dysfunction. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2023 Li, Rosen, Chang, David and Freedman.)
Databáze:	MEDLINE
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