Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and the Risk of Leukoaraiosis in a South Chinese Han Population: A Case-Control Study.

Autor: Mo DC; Department of Neurology, First Affiliated Hospital of Guangxi Medical University, Nanning, China., Wu XJ; Department of Neurology, First Affiliated Hospital of Guangxi Medical University, Nanning, China., Li XL; Department of Neurology, First Affiliated Hospital of Guangxi Medical University, Nanning, China., Liu LY; Department of Neurology, First Affiliated Hospital of Guangxi Medical University, Nanning, China., Jiang YY; Department of Neurology, First Affiliated Hospital of Guangxi Medical University, Nanning, China., Zhou GQ; Department of Neurology, First Affiliated Hospital of Guangxi Medical University, Nanning, China., Chen LJ; Department of Neurology, First Affiliated Hospital of Guangxi Medical University, Nanning, China., Li JX; Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. li.jiao.xing@163.com., Luo M; Department of Neurology, First Affiliated Hospital of Guangxi Medical University, Nanning, China. luoman@gxmu.edu.cn.
Jazyk: angličtina
Zdroj: Biochemical genetics [Biochem Genet] 2024 Aug; Vol. 62 (4), pp. 2353-2361. Date of Electronic Publication: 2023 Nov 01.
DOI: 10.1007/s10528-023-10505-7
Abstrakt: Leukoaraiosis (LA) appears as white matter hyperintensities on T2-weighted brain magnetic resonance imaging scans. Age and hypertension are considered the primary risk factors for LA, but its pathogenesis remains uncertain. This study aims to investigate the correlation between the angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and LA. A total of 140 patients with LA and 136 neuroimaging alteration-free controls were recruited in a case-control study. ACE I/D polymorphism was determined using the polymerase chain reaction method. The allele and genotype distributions of the ACE I/D polymorphism were significantly different between subjects with and without LA. Significant difference was observed in the genotypic distribution between LA patients and controls for recessive and additive models. A statistically significant association remained apparent after adjusting for potential risk factors (D/D vs. I/D + I/I: adjusted OR 3.251, 95% CI 1.185-8.918; D/D vs. I/I: adjusted OR 3.277, 95% CI 1.187-9.047). Our results indicate that the D/D genotype and D allele are important risk factors for LA. Future studies with larger populations are needed to validate our results.
(© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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