Indocyanine green dye and its application in gastrointestinal surgery: The future is bright green.

Autor:	Lim ZY; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore. zavi0002@e.ntu.edu.sg., Mohan S; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore., Balasubramaniam S; Department of General Surgery, Tan Tock Seng Hospital, Singapore 308433, Singapore., Ahmed S; Department of General Surgery, Tan Tock Seng Hospital, Singapore 308433, Singapore., Siew CCH; Department of General Surgery, Tan Tock Seng Hospital, Singapore 308433, Singapore., Shelat VG; Department of General Surgery, Tan Tock Seng Hospital, Singapore 308433, Singapore.
Jazyk:	angličtina
Zdroj:	World journal of gastrointestinal surgery [World J Gastrointest Surg] 2023 Sep 27; Vol. 15 (9), pp. 1841-1857.
DOI:	10.4240/wjgs.v15.i9.1841
Abstrakt:	Indocyanine green (ICG) is a water-soluble fluorescent dye that is minimally toxic and widely used in gastrointestinal surgery. ICG facilitates anatomical identification of structures ( e.g., ureters), assessment of lymph nodes, biliary mapping, organ perfusion and anastomosis assessment, and aids in determining the adequacy of oncological margins. In addition, ICG can be conjugated to artificially created antibodies for tumour markers, such as carcinoembryonic antigen for colorectal, breast, lung, and gastric cancer, prostate-specific antigen for prostate cancer, and cancer antigen 125 for ovarian cancer. Although ICG has shown promising results, the optimization of patient factors, dye factors, equipment, and the method of assessing fluorescence intensity could further enhance its utility. This review summarizes the clinical application of ICG in gastrointestinal surgery and discusses the emergence of novel dyes such as ZW-800 and VM678 that have demonstrated appropriate pharmacokinetic properties and improved target-to-background ratios in animal studies. With the emergence of robotic technology and the increasing reporting of ICG utility, a comprehensive review of clinical application of ICG in gastrointestinal surgery is timely and this review serves that aim. Competing Interests: Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article. (©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.)
Databáze:	MEDLINE
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