Irisin and Cardiometabolic Disorders in Obesity: A Systematic Review.

Autor: Pinho-Jr JDS; Postgraduate Program in Nutrition Sciences, Faculty of Nutrition Emília de Jesus Ferreiro, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.; Systemic Arterial Hypertension Research Center (NuPHAS/UFF), University Hospital Antonio Pedro (HUAP), Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.; Nutrition and Dietetics Department, Faculty of Nutrition Emília de Jesus Ferreiro, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil., Camacho FA; Systemic Arterial Hypertension Research Center (NuPHAS/UFF), University Hospital Antonio Pedro (HUAP), Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.; Postgraduate Program in Cardiovascular Sciences, Faculty of Medicine, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil., Cavararo CDS; Postgraduate Program in Nutrition Sciences, Faculty of Nutrition Emília de Jesus Ferreiro, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.; Systemic Arterial Hypertension Research Center (NuPHAS/UFF), University Hospital Antonio Pedro (HUAP), Fluminense Federal University, Niterói, Rio de Janeiro, Brazil., Baião PF; Systemic Arterial Hypertension Research Center (NuPHAS/UFF), University Hospital Antonio Pedro (HUAP), Fluminense Federal University, Niterói, Rio de Janeiro, Brazil., Medeiros RF; Postgraduate Program in Nutrition Sciences, Faculty of Nutrition Emília de Jesus Ferreiro, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.; Nutrition and Dietetics Department, Faculty of Nutrition Emília de Jesus Ferreiro, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.; Postgraduate Program in Cardiovascular Sciences, Faculty of Medicine, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil., Barroso SG; Postgraduate Program in Nutrition Sciences, Faculty of Nutrition Emília de Jesus Ferreiro, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.; Systemic Arterial Hypertension Research Center (NuPHAS/UFF), University Hospital Antonio Pedro (HUAP), Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.; Nutrition and Dietetics Department, Faculty of Nutrition Emília de Jesus Ferreiro, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil., de Matos AC; Postgraduate Program in Nutrition Sciences, Faculty of Nutrition Emília de Jesus Ferreiro, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.; Systemic Arterial Hypertension Research Center (NuPHAS/UFF), University Hospital Antonio Pedro (HUAP), Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.; Nutrition and Dietetics Department, Faculty of Nutrition Emília de Jesus Ferreiro, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.; Postgraduate Program in Cardiovascular Sciences, Faculty of Medicine, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.
Jazyk: angličtina
Zdroj: International journal of inflammation [Int J Inflam] 2023 Oct 19; Vol. 2023, pp. 5810157. Date of Electronic Publication: 2023 Oct 19 (Print Publication: 2023).
DOI: 10.1155/2023/5810157
Abstrakt: Background: Overweight and obesity are global health issues, impacting a significant portion of young adults. Obesity is a complex condition influenced by genetics and environmental factors, leading to increased susceptibility to cardiovascular diseases (CVDs), hypertension, dyslipidemia, and insulin resistance. Irisin, a protein derived from the cleavage of fibronectin type III domain-containing protein 5, may have relationship with these cardiometabolic diseases.
Objective: This systematic review aims to examine the relationship between serum irisin levels and obesity, particularly in individuals predisposed to cardiovascular risk factors.
Methods: A thorough literature search was conducted in multiple databases, including "Science Direct," "Scopus," "PubMed," and "Lilacs," from July 2020. Inclusion criteria encompassed subjects with metabolic disorders (with or without obesity, BMI ≥30 kg/m 2 ), clinical trials, and observational studies published between 2010 and June 2020. Exclusion criteria were animal studies, meta-analyses, systematic reviews, studies evaluating only healthy subjects, and those investigating disorders beyond cardiometabolic diseases.
Results: Out of 151 identified articles, 30 met the inclusion criteria. These studies, published between 2013 and 2020, assessed adults (≥21 years) and included 26 observational studies and 4 clinical trials ( n  = 7585 subjects). All studies examined irisin's role in obesity and CVDs, often including associated diseases such as type 2 diabetes and hypertension. Despite varying sample sizes, the samples within the articles were homogeneous. Observational studies exhibited a low risk of bias in at least 60% of the evaluated domains. Clinical trials demonstrated a low risk of bias in at least 50% of the domains. Limitations . Although the systematic review provides valuable insights, it is limited by the available literature and the varying methodologies used across studies.
Conclusion: The review suggests that irisin plays a significant role as both a preventive measure and a biomarker for comorbidities linked to obesity and cardiometabolic disorders. Future research should focus on standardized irisin measurement methods and diverse populations to further elucidate its mechanisms of action.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2023 Jorge da Silva Pinho-Jr et al.)
Databáze: MEDLINE
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