Chiranthodendron pentadactylon Larreat ( Sterculiaceae ), a Potential Nephroprotector against Oxidative Damage Provoked by STZ-Induced Hyperglycemia in Rats.

Autor:	Santiago-Balmaseda E; Laboratorio de Toxicología Molecular, Escuela Nacional de Ciencias Biologicas, Campus Unidad Profesional Adolfo Lopez Mateos, Instituto Politecnico Nacional, Ave. Wilfrido Massieu w/n and Closed Street Manuel Stampa, Col. Industrial Vallejo, Mexico City 07700, Mexico.; Laboratorio de Amibas Anfizoicas, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de México. Ave. Barrios 1, Col. Reyes Iztacala, Tlalnepantla de Baz 54090, Mexico., Segura-Cobos D; Laboratorio de Amibas Anfizoicas, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de México. Ave. Barrios 1, Col. Reyes Iztacala, Tlalnepantla de Baz 54090, Mexico., Garín-Aguilar ME; Laboratorio de Farmacobiología, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma de México. Ave. Barrios 1, Col. Reyes Iztacala, Tlalnepantla de Baz 54090, Mexico., San Miguel-Chávez R; Posgrado en Botanica, Campus Montecillo, Colegio de Postgraduados, Mexico-Texcoco Highway Km 35.6, Texcoco Estado de México 56230, Mexico., Cristóbal-Luna JM; Laboratorio de Toxicologia de la Reproduccion, Escuela Nacional de Ciencias Biologicas, Campus Unidad Profesional Adolfo Lopez Mateos, Instituto Politecnico Nacional, Ave. Wilfrido Massieu w/n and Closed Street Manuel Stampa, Col. Industrial Vallejo, Mexico City 07700, Mexico., Madrigal-Santillán E; Laboratorio de Medicina de Conservación, Escuela Superior de Medicina, Campus Unidad Profesional Casco de Santo Tomas, Instituto Politécnico Nacional, Ave. Salvador Díaz Mirón w/n and Closed Street Plan de San Luis, Col. Miguel Hidalgo, Mexico City 11340, Mexico., Gutierrez-Rebolledo GA; Laboratorio de Toxicología Molecular, Escuela Nacional de Ciencias Biologicas, Campus Unidad Profesional Adolfo Lopez Mateos, Instituto Politecnico Nacional, Ave. Wilfrido Massieu w/n and Closed Street Manuel Stampa, Col. Industrial Vallejo, Mexico City 07700, Mexico.; Laboratorio de Toxicologia de la Reproduccion, Escuela Nacional de Ciencias Biologicas, Campus Unidad Profesional Adolfo Lopez Mateos, Instituto Politecnico Nacional, Ave. Wilfrido Massieu w/n and Closed Street Manuel Stampa, Col. Industrial Vallejo, Mexico City 07700, Mexico., Chamorro-Cevallos GA; Laboratorio de Toxicologia de la Reproduccion, Escuela Nacional de Ciencias Biologicas, Campus Unidad Profesional Adolfo Lopez Mateos, Instituto Politecnico Nacional, Ave. Wilfrido Massieu w/n and Closed Street Manuel Stampa, Col. Industrial Vallejo, Mexico City 07700, Mexico., Pérez-Pastén-Borja R; Laboratorio de Toxicología Molecular, Escuela Nacional de Ciencias Biologicas, Campus Unidad Profesional Adolfo Lopez Mateos, Instituto Politecnico Nacional, Ave. Wilfrido Massieu w/n and Closed Street Manuel Stampa, Col. Industrial Vallejo, Mexico City 07700, Mexico.
Jazyk:	angličtina
Zdroj:	Plants (Basel, Switzerland) [Plants (Basel)] 2023 Oct 14; Vol. 12 (20). Date of Electronic Publication: 2023 Oct 14.
DOI:	10.3390/plants12203572
Abstrakt:	Background: Chiranthodendron pentadactylon , known in Mexico as the "tree of the little hands", flower's infusion is used to treat kidney failure associated with diseases such as diabetes. The aim of this work is to evaluate the antioxidant effect of the methanolic extract of its flowers on oxidative damage in kidneys caused by streptozotocin in rats. Methods: The extract phytochemical profile was performed with HPLC. Antioxidant potential in vitro was determined with DPPH and total phenolic tests; antioxidant evaluation in vivo was performed in diabetic rats administered daily via the intragastric route (100 and 200 mg/kg) for 6 weeks; serum glucose/creatinine, food/water consumption, and urinary volume were measured. Relative weight, protein/DNA ratios and oxidative stress were measured in renal tissue. Results: The extract showed 20.53% of total phenolic content and IC 50 of 18.05 µg/mL in DPPH, and this was associated with ferulic acid, phloretin and α-amyrin. Both doses showed a moderate decrease in the protein/DNA ratio in renal tissue, and the same behavior was observed for total urinary protein loss and serum creatinine, while the best antioxidant effect was exerted by a lower dose, which increased catalase activity and decreased lipid peroxidation in the kidneys. Conclusions: Results demonstrated that C. pentadactylon methanolic flower's extract improves renal function through antioxidant mechanisms during experimental diabetes.
Databáze:	MEDLINE
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