Outcomes of low-level light therapy before and after cataract surgery for the prophylaxis of postoperative dry eye: a prospective randomised double-masked controlled clinical trial.

Autor:	Giannaccare G; Department of Ophthalmology, Magna Graecia University of Catanzaro, Catanzaro, Italy giuseppe.giannaccare@gmail.com.; Eye Clinic, Department of Surgical Sciences, University of Cagliari, Cagliari, Italy., Rossi C; Department of Ophthalmology, Magna Graecia University of Catanzaro, Catanzaro, Italy., Borselli M; Department of Ophthalmology, Magna Graecia University of Catanzaro, Catanzaro, Italy., Carnovale Scalzo G; Department of Ophthalmology, Magna Graecia University of Catanzaro, Catanzaro, Italy., Scalia G; Department of Ophthalmology, Magna Graecia University of Catanzaro, Catanzaro, Italy., Pietropaolo R; Department of Ophthalmology, Magna Graecia University of Catanzaro, Catanzaro, Italy., Fratto B; Department of Ophthalmology, Magna Graecia University of Catanzaro, Catanzaro, Italy., Pellegrini M; Department of Ophthalmology, Villa Igea Hospital, Forlì, Italy.; Department of Translational Medicine, University of Ferrara, Ferrara, Italy., Yu AC; Department of Ophthalmology, Villa Igea Hospital, Forlì, Italy.; Department of Translational Medicine, University of Ferrara, Ferrara, Italy., Scorcia V; Department of Ophthalmology, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Jazyk:	angličtina
Zdroj:	The British journal of ophthalmology [Br J Ophthalmol] 2024 Jul 23; Vol. 108 (8), pp. 1172-1176. Date of Electronic Publication: 2024 Jul 23.
DOI:	10.1136/bjo-2023-323920
Abstrakt:	Background: Despite increasing evidence shows that optimising ocular surface before cataract surgery is fundamental in patients with pre-existing dry eye disease (DED) to achieve the desired postoperative outcomes, the prophylactic treatment of healthy patients undergoing surgery aiming at preventing iatrogenic DED is worth investigating. Methods: This was a prospective, interventional, randomised, controlled, double-masked clinical trial. Patients were randomly assigned 1:1 to receive either low-level light therapy (LLLT) or sham treatment (LLLT with a power output <30%). Patients underwent two treatment sessions: 7±2 days before cataract surgery (T0) and 7±2 days after (T1). Outcome measures evaluated 30±4 days after surgery (T2) included Ocular Surface Disease Index (OSDI) questionnaire, non-invasive break-up time (NIBUT), tear meniscus height, meibomian gland loss (MGL) and redness score. Results: Out of 153 patients randomised to receive LLLT (n=73) or sham treatment (n=80), 131 (70 men, 61 women, mean age 73.53±7.29 years) completed regularly the study. Patients treated with LLLT had significantly lower OSDI scores compared with controls at T1 and T2 (respectively, 7.2±8.8 vs 14.8±13.0 and 9.0±9.0 vs 18.2±17.9; both p<0.001), higher NIBUT values at T2 (12.5±6.6 vs 9.0±7.8; p=0.007) and lower MGL Meiboscore values at T1 (1.59±0.70 vs 1.26±0.69; p=0.008). Unlike controls, patients treated with LLLT had significantly lower OSDI scores and higher NIBUT values at T2 compared with T0 (respectively, 9.0±9.0 vs 21.2±16.1; p<0.001 and 12.5±6.6 vs 9.7±7.2; p=0.007). Conclusion: Two sessions of LLLT performed before and after cataract surgery were effective in ameliorating tear film stability and ocular discomfort symptoms. Trial Registration Number: NCT05754437. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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