Analyzing COVID-19 Vaccine Responses in Transplant Recipients.

Autor:	Murali TM; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; NUS-Cambridge Immune Phenotyping Centre, Life Sciences Institute, National University of Singapore, Singapore., Shunmuganathan B; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore., Trueman EL; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Gupta R; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Tan RSW; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Sran HK; National University Centre for Organ Transplantation, National University Hospital, Singapore., D'Costa MR; National University Centre for Organ Transplantation, National University Hospital, Singapore., Wong ET; National University Centre for Organ Transplantation, National University Hospital, Singapore., Gu Y; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Cui J; Immunology Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Wee Kun K; National University Centre for Organ Transplantation, National University Hospital, Singapore., Lim AQH; National University Centre for Organ Transplantation, National University Hospital, Singapore., Qian X; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore., Purushotorman K; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; NUS-Cambridge Immune Phenotyping Centre, Life Sciences Institute, National University of Singapore, Singapore.; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore., Chen J; Immunology Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Singapore Immunology Network, Agency for Science, Technology and Research, Singapore., MacAry PA; Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; NUS-Cambridge Immune Phenotyping Centre, Life Sciences Institute, National University of Singapore, Singapore.; Antibody Engineering Programme, Life Sciences Institute, National University of Singapore, Singapore.; Immunology Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Vathsala A; National University Centre for Organ Transplantation, National University Hospital, Singapore.; Department of Medicine, National University of Singapore, Singapore.
Jazyk:	angličtina
Zdroj:	ImmunoHorizons [Immunohorizons] 2023 Oct 01; Vol. 7 (10), pp. 708-717.
DOI:	10.4049/immunohorizons.2300071
Abstrakt:	COVID-19 vaccination has significantly impacted the global pandemic by reducing the severity of infection, lowering rates of hospitalization, and reducing morbidity/mortality in healthy individuals. However, the degree of vaccine-induced protection afforded to renal transplant recipients who receive forms of maintenance immunosuppression remains poorly defined. This is particularly important when we factor in the emergence of SARS-CoV-2 variants of concern (VOCs) that have defined mutations that reduce the effectiveness of Ab responses targeting the Spike Ags from the ancestral Wuhan-Hu-1 variants employed in the most widely used vaccine formats. In this study, we describe a qualitative, longitudinal analysis of neutralizing Ab responses against multiple SARS-CoV-2 VOCs in 129 renal transplant recipients who have received three doses of the Pfizer-BioNTech COVID-19 vaccine (BNT162b2). Our results reveal a qualitative and quantitative reduction in the vaccine-induced serological response in transplant recipients versus healthy controls where only 51.9% (67 of 129) made a measurable vaccine-induced IgG response and 41.1% (53 of 129) exhibited a significant neutralizing Ab titer (based on a pseudovirus neutralization test value >50%). Analysis on the VOCs revealed strongest binding toward the wild-type Wuhan-Hu-1 and Delta variants but none with both of the Omicron variants tested (BA1 and BA2). Moreover, older transplant recipients and those who are on mycophenolic acid as part of their maintenance therapy exhibited a profound reduction in all of the analyzed vaccine-induced immune correlates. These data have important implications for how we monitor and manage transplant patients in the future as COVID-19 becomes endemic in our populations. (Copyright © 2023 The Authors.)
Databáze:	MEDLINE
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