Evolutionary consequences of nascent multicellular life cycles.

Autor:	Pentz JT; Los Alamos National Laboratory, Los Alamos, United States., MacGillivray K; School of Biological Sciences, Georgia Institute of Technology, Atlanta, United States.; Interdisciplinary Graduate Program in Quantitative Biosciences, Georgia Institute of Technology, Atlanta, United States., DuBose JG; School of Biological Sciences, Georgia Institute of Technology, Atlanta, United States., Conlin PL; School of Biological Sciences, Georgia Institute of Technology, Atlanta, United States., Reinhardt E; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, United States., Libby E; IceLab, Umeå University, Umeå, Sweden., Ratcliff WC; School of Biological Sciences, Georgia Institute of Technology, Atlanta, United States.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2023 Oct 27; Vol. 12. Date of Electronic Publication: 2023 Oct 27.
DOI:	10.7554/eLife.84336
Abstrakt:	A key step in the evolutionary transition to multicellularity is the origin of multicellular groups as biological individuals capable of adaptation. Comparative work, supported by theory, suggests clonal development should facilitate this transition, although this hypothesis has never been tested in a single model system. We evolved 20 replicate populations of otherwise isogenic clonally reproducing 'snowflake' yeast (Δ ace2/∆ace2 ) and aggregative 'floc' yeast ( GAL1 p ::FLO1 /GAL1 p ::FLO1 ) with daily selection for rapid growth in liquid media, which favors faster cell division, followed by selection for rapid sedimentation, which favors larger multicellular groups. While both genotypes adapted to this regime, growing faster and having higher survival during the group-selection phase, there was a stark difference in evolutionary dynamics. Aggregative floc yeast obtained nearly all their increased fitness from faster growth, not improved group survival; indicating that selection acted primarily at the level of cells. In contrast, clonal snowflake yeast mainly benefited from higher group-dependent fitness, indicating a shift in the level of Darwinian individuality from cells to groups. Through genome sequencing and mathematical modeling, we show that the genetic bottlenecks in a clonal life cycle also drive much higher rates of genetic drift-a result with complex implications for this evolutionary transition. Our results highlight the central role that early multicellular life cycles play in the process of multicellular adaptation. Competing Interests: JP, KM, JD, PC, ER, EL, WR No competing interests declared
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu