A feasibility study on exhaled breath analysis using UV spectroscopy to detect COVID-19.

Autor:	Sutaria SR; Departments of Chemistry, University of Louisville, Louisville, KY 40292, United States of America., Morris JD; Chemical Engineering, University of Louisville, Louisville, KY 40292, United States of America., Xie Z; Chemical Engineering, University of Louisville, Louisville, KY 40292, United States of America., Cooke EA; Anesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY 40292, United States of America., Silvers SM; Anesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY 40292, United States of America., Long GA; Anesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY 40292, United States of America., Balcom D; Division of Infectious Diseases, Department of Medicine, University of Louisville, Louisville, KY 40292, United States of America., Marimuthu S; Division of Infectious Diseases, Department of Medicine, University of Louisville, Louisville, KY 40292, United States of America., Parrish LW; Division of Infectious Diseases, Department of Medicine, University of Louisville, Louisville, KY 40292, United States of America., Aliesky H; Division of Infectious Diseases, Department of Medicine, University of Louisville, Louisville, KY 40292, United States of America., Arnold FW; Division of Infectious Diseases, Department of Medicine, University of Louisville, Louisville, KY 40292, United States of America., Huang J; Anesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY 40292, United States of America., Fu XA; Chemical Engineering, University of Louisville, Louisville, KY 40292, United States of America., Nantz MH; Departments of Chemistry, University of Louisville, Louisville, KY 40292, United States of America.
Jazyk:	angličtina
Zdroj:	Journal of breath research [J Breath Res] 2023 Nov 02; Vol. 18 (1). Date of Electronic Publication: 2023 Nov 02.
DOI:	10.1088/1752-7163/ad0646
Abstrakt:	A 23-subject feasibility study is reported to assess how UV absorbance measurements on exhaled breath samples collected from silicon microreactors can be used to detect COVID-19. The silicon microreactor technology chemoselectively preconcentrates exhaled carbonyl volatile organic compounds and subsequent methanol elution provides samples for analysis. The underlying scientific rationale that viral infection will induce an increase in exhaled carbonyls appears to be supported by the results of the feasibility study. The data indicate statistically significant differences in measured UV absorbance values between healthy and symptomatic COVID-19 positive subjects in the wavelength range from 235 nm to 305 nm. Factors such as subject age were noted as potential confounding variables. (Creative Commons Attribution license.)
Databáze:	MEDLINE
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